SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides

SARM1 is a key regulator of a conserved program of axon degeneration increasingly linked to human neurodegenerative diseases. Pathological SARM1 activation causes rapid NAD consumption, disrupting cellular homeostasis and leading to axon degeneration. In this study, we develop antisense oligonucleot...

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Bibliographic Details
Main Authors: Andrea Loreto, Kaitlyn M.L. Cramb, Lucy A. McDermott, Christina Antoniou, Ilenia Cirilli, Maria Claudia Caiazza, Elisa Merlini, Peter Arthur-Farraj, W. Daniel du Preez, Elliot D. Mock, Hien T. Zhao, David L. Bennett, Giuseppe Orsomando, Michael P. Coleman, Richard Wade-Martins
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
SARM1
Vacor
ASO
Nicotinamide
Axon degeneration
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002025
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