Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level
Introduction The aim of the study was to evaluate chemerin levels as a potentially useful marker in diagnosing early-stage hepatocellular carcinoma (HCC) as well as in HCC staging. Material and methods The cohort comprised 76 patients: 45 people with cirrhosis and HCC (including 13 with a single HC...
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Termedia Publishing House
2024-10-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/Serum-chemerin-level-in-patients-with-liver-cirrhosis-and-primary-and-multifocal,176674,0,2.html |
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| author | Monika Pazgan-Simon Anna Szymanek-Pasternal Joanna Górka-Dynysiewicz Anna Nowicka Krzysztof Simon Ewa Grzebyk Michał Kukla |
| author_facet | Monika Pazgan-Simon Anna Szymanek-Pasternal Joanna Górka-Dynysiewicz Anna Nowicka Krzysztof Simon Ewa Grzebyk Michał Kukla |
| author_sort | Monika Pazgan-Simon |
| collection | DOAJ |
| description | Introduction
The aim of the study was to evaluate chemerin levels as a potentially useful marker in diagnosing early-stage hepatocellular carcinoma (HCC) as well as in HCC staging.
Material and methods
The cohort comprised 76 patients: 45 people with cirrhosis and HCC (including 13 with a single HCC lesion in the liver and 32 with metastatic lesions/spread of HCC in the liver) and 21 people with isolated cirrhosis. The control group included 10 clinically healthy people.
Results
The degree of liver failure in the whole cohort was assessed using the Child-Turcotte-Pugh (CTP) score (class A – 34, class B – 28, class C – 4) and using the MELD score (≤ 12 points – 45 and > 12 points – 21 people). Serum chemerin level in patients with liver cirrhosis only was 53.30 ng/ml, in patients with a single HCC lesion 77.01 ng/ml, and in patients with disseminated HCC 83.58 ng/ml. In the control group, the chemerin level was 82.20 µg/ml. When patients with cirrhosis and with/without HCC were divided according to their CTP scores, the level of chemerin was as follows: class A – 83.90 µg/ml, class B – 61 µg/ml, class C – 30.10 µg/ml. For MELD scores ≤ and > 12 it was 75 µg/ml and 58 µg/ml, respectively. For BCLC staging the results were as follows: A – 20.10 µg/ml, B – 20.20 µg/ml, C –19.44 µg/ml.
Conclusions
Chemerin increases with the number of neoplastic lesions and decreases with the progression of liver failure as assessed using the CTP score. |
| format | Article |
| id | doaj-art-e79a533b33e64e5cb9225e9c62c85326 |
| institution | Kabale University |
| issn | 1734-1922 1896-9151 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj-art-e79a533b33e64e5cb9225e9c62c853262025-01-27T10:44:31ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512024-10-012051504151010.5114/aoms/176674176674Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin levelMonika Pazgan-Simon0Anna Szymanek-Pasternal1Joanna Górka-Dynysiewicz2Anna Nowicka3Krzysztof Simon4Ewa Grzebyk5Michał Kukla6Department of Infectious Disease and Hepatology, Regional Specialistic Hospital, Wrocław, PolandDepartment of Infectious Disease and Hepatology, Regional Specialistic Hospital, Wrocław, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, PolandDepartment of Infectious Disease and Hepatology, Regional Specialistic Hospital, Wrocław, PolandDepartment of Infectious Disease and Hepatology, Regional Specialistic Hospital, Wrocław, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, PolandEndoscopy Unit, Department of Internal Medicine and Geriatrics, Medical College Jagiellonian University, University Hospital, Krakow, PolandIntroduction The aim of the study was to evaluate chemerin levels as a potentially useful marker in diagnosing early-stage hepatocellular carcinoma (HCC) as well as in HCC staging. Material and methods The cohort comprised 76 patients: 45 people with cirrhosis and HCC (including 13 with a single HCC lesion in the liver and 32 with metastatic lesions/spread of HCC in the liver) and 21 people with isolated cirrhosis. The control group included 10 clinically healthy people. Results The degree of liver failure in the whole cohort was assessed using the Child-Turcotte-Pugh (CTP) score (class A – 34, class B – 28, class C – 4) and using the MELD score (≤ 12 points – 45 and > 12 points – 21 people). Serum chemerin level in patients with liver cirrhosis only was 53.30 ng/ml, in patients with a single HCC lesion 77.01 ng/ml, and in patients with disseminated HCC 83.58 ng/ml. In the control group, the chemerin level was 82.20 µg/ml. When patients with cirrhosis and with/without HCC were divided according to their CTP scores, the level of chemerin was as follows: class A – 83.90 µg/ml, class B – 61 µg/ml, class C – 30.10 µg/ml. For MELD scores ≤ and > 12 it was 75 µg/ml and 58 µg/ml, respectively. For BCLC staging the results were as follows: A – 20.10 µg/ml, B – 20.20 µg/ml, C –19.44 µg/ml. Conclusions Chemerin increases with the number of neoplastic lesions and decreases with the progression of liver failure as assessed using the CTP score.https://www.archivesofmedicalscience.com/Serum-chemerin-level-in-patients-with-liver-cirrhosis-and-primary-and-multifocal,176674,0,2.htmlliver cirrhosishepatocellular carcinomachemerin levelinsulin resistance |
| spellingShingle | Monika Pazgan-Simon Anna Szymanek-Pasternal Joanna Górka-Dynysiewicz Anna Nowicka Krzysztof Simon Ewa Grzebyk Michał Kukla Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level Archives of Medical Science liver cirrhosis hepatocellular carcinoma chemerin level insulin resistance |
| title | Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| title_full | Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| title_fullStr | Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| title_full_unstemmed | Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| title_short | Serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| title_sort | serum chemerin level in patients with liver cirrhosis and primary and multifocal hepatocellular carcinoma with consideration of insulin level |
| topic | liver cirrhosis hepatocellular carcinoma chemerin level insulin resistance |
| url | https://www.archivesofmedicalscience.com/Serum-chemerin-level-in-patients-with-liver-cirrhosis-and-primary-and-multifocal,176674,0,2.html |
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