Optimal intrapleural therapy with alpha-hemolytic streptococci bio-product (Mannatide) in controlling malignant pleural effusion: a clustered systematic review and meta-analysis

Optimal intrapleural therapy with alpha-hemolytic streptococci bio-product (Mannatide) in controlling malignant pleural effusion: a clustered systematic review and meta-analysis

Abstract Background Mannatide is an alpha-hemolytic streptococci bio-product. We conducted a comprehensive clustered systematic review and meta-analysis to reveal the clinical values of Mannatide for controlling malignant pleural effusion (MPE), identify the optimal therapeutic regimens, indications...

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Main Authors:	Yan Zhang, Xiao-Tian Zheng, Jiao Xu, Da-Chun Cai, Feng Luo, Jun Huang, Yan-Yan Jin, Teng-Yang Fan, Ji-Hong Feng, Xue Xiao, Zheng Xiao
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	BMC Cancer
Subjects:	Alpha-hemolytic streptococci Mannatide Malignant pleural effusion (MPE) Randomized controlled trials (RCTs) Clustered systematic review
Online Access:	https://doi.org/10.1186/s12885-025-14541-x
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