Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization
Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Methods. We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluate...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/651501 |
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| author | Ievgenia Pastushenko Tamara Gracia-Cazaña Sandra Vicente-Arregui Gert G. Van den Eynden Mariano Ara Peter B. Vermeulen Franciso José Carapeto Steven J. Van Laere |
| author_facet | Ievgenia Pastushenko Tamara Gracia-Cazaña Sandra Vicente-Arregui Gert G. Van den Eynden Mariano Ara Peter B. Vermeulen Franciso José Carapeto Steven J. Van Laere |
| author_sort | Ievgenia Pastushenko |
| collection | DOAJ |
| description | Aims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Methods. We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluated the relative blood vessel area using the Chalkley counting method in each histologic subtype of these tumours. We calculated the degree of proliferation of blood vessel endothelium dividing CD105-Chalkley score by CD31-Chalkley score. Results. We found significantly higher peritumoral and intratumoral blood vessel area in SCC when compared to BCC (both with CD31 and CD105). Chalkley counts differed significantly between groups with different BCC histologic subtypes and SCC with different grade of differentiation. Surprisingly, the degree of proliferation of blood vessel endothelium was higher in BCC when compared to SCC. Conclusions. While SCC exhibited significantly higher intratumoral and peritumoral blood vessel areas compared to BCC, the relatively low rate of proliferating endothelium in this tumour type suggests the existence of endothelial-sprouting-independent mechanisms of vascularization in SCC. |
| format | Article |
| id | doaj-art-e78ffb1d8f244435b5203a8293ad8a60 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-e78ffb1d8f244435b5203a8293ad8a602025-02-03T01:00:10ZengWileyJournal of Skin Cancer2090-29052090-29132014-01-01201410.1155/2014/651501651501Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour VascularizationIevgenia Pastushenko0Tamara Gracia-Cazaña1Sandra Vicente-Arregui2Gert G. Van den Eynden3Mariano Ara4Peter B. Vermeulen5Franciso José Carapeto6Steven J. Van Laere7Department of Dermatology, University Hospital “Clinico Lozano Blesa,” Calle San Juan Bosco 15, 50009 Zaragoza, SpainDepartment of Dermatology, University Hospital “Clinico Lozano Blesa,” Calle San Juan Bosco 15, 50009 Zaragoza, SpainDepartment of Pathology, University Hospital “Miguel Servet,” Paseo Isabel la Católica 1-3, 50009 Zaragoza, SpainTranslational Cancer Research Unit Antwerp, Oncology Centre, General Hospital Sint-Augustinus, Oosterveldlaan 24, 2610 Wilrijk, BelgiumDepartment of Dermatology, University Hospital “Clinico Lozano Blesa,” Calle San Juan Bosco 15, 50009 Zaragoza, SpainTranslational Cancer Research Unit Antwerp, Oncology Centre, General Hospital Sint-Augustinus, Oosterveldlaan 24, 2610 Wilrijk, BelgiumDepartment of Medicine, Psychiatry and Dermatology, School of Medicine, University of Zaragoza, Calle Domingo Miral s/n, 50009 Zaragoza, SpainDepartment of Pathology, University Hospital “Miguel Servet,” Paseo Isabel la Católica 1-3, 50009 Zaragoza, SpainAims. To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin. Methods. We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluated the relative blood vessel area using the Chalkley counting method in each histologic subtype of these tumours. We calculated the degree of proliferation of blood vessel endothelium dividing CD105-Chalkley score by CD31-Chalkley score. Results. We found significantly higher peritumoral and intratumoral blood vessel area in SCC when compared to BCC (both with CD31 and CD105). Chalkley counts differed significantly between groups with different BCC histologic subtypes and SCC with different grade of differentiation. Surprisingly, the degree of proliferation of blood vessel endothelium was higher in BCC when compared to SCC. Conclusions. While SCC exhibited significantly higher intratumoral and peritumoral blood vessel areas compared to BCC, the relatively low rate of proliferating endothelium in this tumour type suggests the existence of endothelial-sprouting-independent mechanisms of vascularization in SCC.http://dx.doi.org/10.1155/2014/651501 |
| spellingShingle | Ievgenia Pastushenko Tamara Gracia-Cazaña Sandra Vicente-Arregui Gert G. Van den Eynden Mariano Ara Peter B. Vermeulen Franciso José Carapeto Steven J. Van Laere Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization Journal of Skin Cancer |
| title | Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization |
| title_full | Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization |
| title_fullStr | Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization |
| title_full_unstemmed | Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization |
| title_short | Squamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization |
| title_sort | squamous cell carcinomas of the skin explore angiogenesis independent mechanisms of tumour vascularization |
| url | http://dx.doi.org/10.1155/2014/651501 |
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