Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae

Loss of OmpK35 and Glycine-aspartic acid Duplication in ompK36 Negatively Affect the in vitro Synergy of Meropenem in Combination with Piperacillin/tazobactam or Imipenem Against OXA-48-like Carbapenemase-producing Klebsiella pneumoniae

BACKGROUND-AIM: Although ceftazidime/avibactam is the agent of choice in OXA-48-producing Klebsiella pneumoniae infections, it is not readily available or prohibitively expensive in many countries. Since piperacillin/tazobactam plus meropenem combination was recently reported as highly synergistic a...

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Main Authors: Abdullah Tarik Aslan, Mervenur Demir, Elif Seren Tanriverdi, Budi Permana, Rhys Izuagbe, Kay A. Ramsay, Brian Forde, Baris Otlu, David L. Paterson, Patrick Harris, Murat Akova, Gulsen Hazirolan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Synergy
in vitro
OXA-48
Klebsiella pneumoniae
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716524001966
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