Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old
Background. Neutrophil to lymphocyte ratio (NLR) is a new inflammatory marker; the relationship between NLR and adverse cardiovascular (CV) prognosis has been gradually emphasized in the general population. However, their association in peritoneal dialysis (PD) patients remains unclear. Methods. Fro...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/4634736 |
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| author | Yingsi Zeng Zijun Chen Qinkai Chen Xiaojiang Zhan Haibo Long Fenfen Peng Fengping Zhang Xiaoran Feng Qian Zhou Lingling Liu Xuan Peng Evergreen Tree Nephrology Association Guanhua Guo Yujing Zhang Zebin Wang Yueqiang Wen Jiao Li Jianbo Liang |
| author_facet | Yingsi Zeng Zijun Chen Qinkai Chen Xiaojiang Zhan Haibo Long Fenfen Peng Fengping Zhang Xiaoran Feng Qian Zhou Lingling Liu Xuan Peng Evergreen Tree Nephrology Association Guanhua Guo Yujing Zhang Zebin Wang Yueqiang Wen Jiao Li Jianbo Liang |
| author_sort | Yingsi Zeng |
| collection | DOAJ |
| description | Background. Neutrophil to lymphocyte ratio (NLR) is a new inflammatory marker; the relationship between NLR and adverse cardiovascular (CV) prognosis has been gradually emphasized in the general population. However, their association in peritoneal dialysis (PD) patients remains unclear. Methods. From January 1, 2010, to May 31, 2017, a total of 1652 patients were recruited. NLR was categorized in triplicates: NLR≤2.74, 2.74<NLR≤3.96, and NLR>3.96. Kaplan-Meier cumulative incidence curve and multivariable COX regression analysis were used to determine the relationship between NLR and the incidence of adverse CV outcome, while a competitive risk model was applied to assess the effects of other outcomes on adverse CV prognosis. Besides, forest plot was investigated to analyze the adverse CV prognosis in different subgroups. Results. During follow-up, 213 new-onset CV events and 153 CV disease (CVD) deaths were recorded. Multivariable COX regression models showed that the highest tertile of NLR level was associated with increased risk of CV events (HR=1.39, 95%CI=1.01‐1.93, P=0.046) and CVD mortality (HR=1.81, 95%CI=1.22‐2.69, P=0.003), while compared to the lowest tertile. Competitive risk models showed that the differences in CV event (P<0.001) and CVD mortality (P=0.004) among different NLR groups were still significant while excluding the effects of other outcomes. In subgroups, with each 1 increased in the NLR level, adjusted HR of new-onset CV event was 2.02 (95%CI=1.26−3.23, P=0.003) and CVD mortality was 2.98 (95%CI=1.58−5.62, P=0.001) in the younger group (age<60 years). Conclusions. NLR is an independent risk factor for adverse CV prognosis in PD patients younger than 60 years old. |
| format | Article |
| id | doaj-art-e7885c81f3d64a1eb92a4a2f7c93229b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-e7885c81f3d64a1eb92a4a2f7c93229b2025-02-03T01:00:05ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/46347364634736Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years OldYingsi Zeng0Zijun Chen1Qinkai Chen2Xiaojiang Zhan3Haibo Long4Fenfen Peng5Fengping Zhang6Xiaoran Feng7Qian Zhou8Lingling Liu9Xuan Peng10Evergreen Tree Nephrology Association11Guanhua Guo12Yujing Zhang13Zebin Wang14Yueqiang Wen15Jiao Li16Jianbo Liang17Department of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, Affiliated Dongguan People's Hospital, Southern Medical University, Guangdong, ChinaDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Nephrology, Jiujiang No. 1 People’s Hospital, Jiangxi, ChinaDepartment of Nephrology, Jiujiang No. 1 People’s Hospital, Jiangxi, ChinaDepartment of Medical Statistics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of General Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaEvergreen Tree Nephrology Association, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaBackground. Neutrophil to lymphocyte ratio (NLR) is a new inflammatory marker; the relationship between NLR and adverse cardiovascular (CV) prognosis has been gradually emphasized in the general population. However, their association in peritoneal dialysis (PD) patients remains unclear. Methods. From January 1, 2010, to May 31, 2017, a total of 1652 patients were recruited. NLR was categorized in triplicates: NLR≤2.74, 2.74<NLR≤3.96, and NLR>3.96. Kaplan-Meier cumulative incidence curve and multivariable COX regression analysis were used to determine the relationship between NLR and the incidence of adverse CV outcome, while a competitive risk model was applied to assess the effects of other outcomes on adverse CV prognosis. Besides, forest plot was investigated to analyze the adverse CV prognosis in different subgroups. Results. During follow-up, 213 new-onset CV events and 153 CV disease (CVD) deaths were recorded. Multivariable COX regression models showed that the highest tertile of NLR level was associated with increased risk of CV events (HR=1.39, 95%CI=1.01‐1.93, P=0.046) and CVD mortality (HR=1.81, 95%CI=1.22‐2.69, P=0.003), while compared to the lowest tertile. Competitive risk models showed that the differences in CV event (P<0.001) and CVD mortality (P=0.004) among different NLR groups were still significant while excluding the effects of other outcomes. In subgroups, with each 1 increased in the NLR level, adjusted HR of new-onset CV event was 2.02 (95%CI=1.26−3.23, P=0.003) and CVD mortality was 2.98 (95%CI=1.58−5.62, P=0.001) in the younger group (age<60 years). Conclusions. NLR is an independent risk factor for adverse CV prognosis in PD patients younger than 60 years old.http://dx.doi.org/10.1155/2020/4634736 |
| spellingShingle | Yingsi Zeng Zijun Chen Qinkai Chen Xiaojiang Zhan Haibo Long Fenfen Peng Fengping Zhang Xiaoran Feng Qian Zhou Lingling Liu Xuan Peng Evergreen Tree Nephrology Association Guanhua Guo Yujing Zhang Zebin Wang Yueqiang Wen Jiao Li Jianbo Liang Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old Mediators of Inflammation |
| title | Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old |
| title_full | Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old |
| title_fullStr | Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old |
| title_full_unstemmed | Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old |
| title_short | Neutrophil to Lymphocyte Ratio Predicts Adverse Cardiovascular Outcome in Peritoneal Dialysis Patients Younger than 60 Years Old |
| title_sort | neutrophil to lymphocyte ratio predicts adverse cardiovascular outcome in peritoneal dialysis patients younger than 60 years old |
| url | http://dx.doi.org/10.1155/2020/4634736 |
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