Association of pruritus and chronic cough: an all of us database study
Purpose Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the All of Us database, examines the association between the two conditions.Materials and methods A nested case-control com...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2024.2355976 |
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| _version_ | 1850063639226089472 |
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| author | Divija Sharma Juliana Pulsinelli Joel Correa da Rosa Zhen Wang Brian Kim Benjamin Ungar |
| author_facet | Divija Sharma Juliana Pulsinelli Joel Correa da Rosa Zhen Wang Brian Kim Benjamin Ungar |
| author_sort | Divija Sharma |
| collection | DOAJ |
| description | Purpose Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the All of Us database, examines the association between the two conditions.Materials and methods A nested case-control comparison was used to examine the association, identifying cases with SNOMED codes 418363000 (pruritus) and 68154008 (CC). Matching was performed on a 1:4 ratio by age, sex, and ethnicity using the MatchIt package in R, followed by maximum likelihood method to estimate odds ratios (ORs) and 95% confidence intervals from 2x2 contingency tables.Results CC patients (n = 2,388) were more than twice as likely to be diagnosed with pruritus (OR: 2.65) and pruritus patients (n = 22,496) were more than twice as likely to be diagnosed with CC (OR: 2.57), than respective matched controls.Conclusions These results highlight the potential bidirectional relationship between CC and pruritus, suggesting possible shared immune and neural pathways. Treatments like difelikefalin and nalbuphine that modulate these pathways, alongside P2X3 targeting agents, are emerging as potential therapeutic approaches for itch and chronic cough given the possible interconnected pathophysiology. This study’s insights into the associations between pruritus and CC may pave the way for targeted therapeutic strategies that address their shared mechanisms. |
| format | Article |
| id | doaj-art-e78103f869194dc2b7e9ce4e6f1c7bd0 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-e78103f869194dc2b7e9ce4e6f1c7bd02025-08-20T02:49:32ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532024-12-0135110.1080/09546634.2024.2355976Association of pruritus and chronic cough: an all of us database studyDivija Sharma0Juliana Pulsinelli1Joel Correa da Rosa2Zhen Wang3Brian Kim4Benjamin Ungar5Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USAPurpose Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the All of Us database, examines the association between the two conditions.Materials and methods A nested case-control comparison was used to examine the association, identifying cases with SNOMED codes 418363000 (pruritus) and 68154008 (CC). Matching was performed on a 1:4 ratio by age, sex, and ethnicity using the MatchIt package in R, followed by maximum likelihood method to estimate odds ratios (ORs) and 95% confidence intervals from 2x2 contingency tables.Results CC patients (n = 2,388) were more than twice as likely to be diagnosed with pruritus (OR: 2.65) and pruritus patients (n = 22,496) were more than twice as likely to be diagnosed with CC (OR: 2.57), than respective matched controls.Conclusions These results highlight the potential bidirectional relationship between CC and pruritus, suggesting possible shared immune and neural pathways. Treatments like difelikefalin and nalbuphine that modulate these pathways, alongside P2X3 targeting agents, are emerging as potential therapeutic approaches for itch and chronic cough given the possible interconnected pathophysiology. This study’s insights into the associations between pruritus and CC may pave the way for targeted therapeutic strategies that address their shared mechanisms.https://www.tandfonline.com/doi/10.1080/09546634.2024.2355976Chronic coughitchpruritusmast cell dysfunctioncentral sensitization |
| spellingShingle | Divija Sharma Juliana Pulsinelli Joel Correa da Rosa Zhen Wang Brian Kim Benjamin Ungar Association of pruritus and chronic cough: an all of us database study Journal of Dermatological Treatment Chronic cough itch pruritus mast cell dysfunction central sensitization |
| title | Association of pruritus and chronic cough: an all of us database study |
| title_full | Association of pruritus and chronic cough: an all of us database study |
| title_fullStr | Association of pruritus and chronic cough: an all of us database study |
| title_full_unstemmed | Association of pruritus and chronic cough: an all of us database study |
| title_short | Association of pruritus and chronic cough: an all of us database study |
| title_sort | association of pruritus and chronic cough an all of us database study |
| topic | Chronic cough itch pruritus mast cell dysfunction central sensitization |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2024.2355976 |
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