The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control
Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/328372 |
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| author | Jean-Philippe Guégan Christophe Frémin Georges Baffet |
| author_facet | Jean-Philippe Guégan Christophe Frémin Georges Baffet |
| author_sort | Jean-Philippe Guégan |
| collection | DOAJ |
| description | Primary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models. |
| format | Article |
| id | doaj-art-e77fd99b08dc4145b999b94812107268 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-e77fd99b08dc4145b999b948121072682025-02-03T01:03:46ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/328372328372The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle ControlJean-Philippe Guégan0Christophe Frémin1Georges Baffet2Inserm, U1085, Institut de Recherche sur la Santé l’Environnement et le Travail (IRSET), Université de Rennes 1, SFR Biosit, 35043 Rennes, FranceInserm, U1085, Institut de Recherche sur la Santé l’Environnement et le Travail (IRSET), Université de Rennes 1, SFR Biosit, 35043 Rennes, FranceInserm, U1085, Institut de Recherche sur la Santé l’Environnement et le Travail (IRSET), Université de Rennes 1, SFR Biosit, 35043 Rennes, FrancePrimary cultures of hepatocytes are powerful models in studying the sequence of events that are necessary for cell progression from a G0-like state to S phase. The models mimic the physiological process of hepatic regeneration after liver injury or partial hepatectomy. Many reports suggest that the mitogen-activated protein kinase (MAPK) ERK1/2 can support hepatocyte proliferation in vitro and in vivo and the MEK/ERK cascade acts as an essential element in hepatocyte responses induced by the EGF. Moreover, its disregulation has been associated with the promotion of tumor cell growth of a variety of tumors, including hepatocellular carcinoma. Whereas the strict specificity of action of ERK1 and ERK2 is still debated, the MAPKs may have specific biological functions under certain contexts and according to the differentiation status of the cells, notably hepatocytes. In this paper, we will focus on MEK1/2-ERK1/2 activations and roles in normal rodent hepatocytes in vitro and in vivo after partial hepatectomy and in human hepatocarcinoma cells. The possible specificity of ERK1 and ERK2 in normal and transformed hepatocyte will be discussed in regard to other differentiated and undifferentiated cellular models.http://dx.doi.org/10.1155/2012/328372 |
| spellingShingle | Jean-Philippe Guégan Christophe Frémin Georges Baffet The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control International Journal of Hepatology |
| title | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control |
| title_full | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control |
| title_fullStr | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control |
| title_full_unstemmed | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control |
| title_short | The MAPK MEK1/2-ERK1/2 Pathway and Its Implication in Hepatocyte Cell Cycle Control |
| title_sort | mapk mek1 2 erk1 2 pathway and its implication in hepatocyte cell cycle control |
| url | http://dx.doi.org/10.1155/2012/328372 |
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