Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice
Abstract Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, p...
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-55917-8 |
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| author | Jing Geng Xiaoliang Zhang Yanjie Guo He Wen Dong Guo Qi Liang Siying Pu Ying Wang Mingchuan Liu Zhelong Li Wei Hu Xue Yang Pan Chang Lang Hu Yan Li |
| author_facet | Jing Geng Xiaoliang Zhang Yanjie Guo He Wen Dong Guo Qi Liang Siying Pu Ying Wang Mingchuan Liu Zhelong Li Wei Hu Xue Yang Pan Chang Lang Hu Yan Li |
| author_sort | Jing Geng |
| collection | DOAJ |
| description | Abstract Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, physical exercise prevented HFCD-induced whole-body fat deposition. However, physical exercise exacerbated HFCD-induced cardiac damage. Further metabolomic analysis results showed that physical exercise induced circulating lipid redistribution, leading to excessive cardiac lipid uptake and lipotoxicity. Our study provides valuable insights into the cardiac effects of exercise in mice fed with HFCD, suggesting that counteracting the negative effect of HFCD by simultaneous physical exercise might be detrimental. Moreover, inappropriate physical exercise may damage certain organs even though it leads to weight loss and overall metabolic benefits. Of note, the current findings are based on animal experiments, the generalizability of these findings beyond this specific diet and mouse strain remains to be further explored. |
| format | Article |
| id | doaj-art-e77fab70628343309a7f2c2df51fdfc2 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-e77fab70628343309a7f2c2df51fdfc22025-02-02T12:31:44ZengNature PortfolioNature Communications2041-17232025-01-0116111810.1038/s41467-025-55917-8Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed miceJing Geng0Xiaoliang Zhang1Yanjie Guo2He Wen3Dong Guo4Qi Liang5Siying Pu6Ying Wang7Mingchuan Liu8Zhelong Li9Wei Hu10Xue Yang11Pan Chang12Lang Hu13Yan Li14Department of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityXi’an International Medical Center HospitalDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Ultrasound Diagnostics, Tangdu Hospital, Airforce Medical UniversityDepartment of Ultrasound Diagnostics, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, The Second Affiliated Hospital of Xi’an Medical CollegeDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityDepartment of Cardiology, Tangdu Hospital, Airforce Medical UniversityAbstract Physical exercise is a cornerstone for preventing diet-induced obesity, while it is unclear whether physical exercise could offset high-fat, high-calories diet (HFCD)-induced cardiac dysfunction. Here, mice were fed with HFCD and simultaneously subjected to physical exercise. As expected, physical exercise prevented HFCD-induced whole-body fat deposition. However, physical exercise exacerbated HFCD-induced cardiac damage. Further metabolomic analysis results showed that physical exercise induced circulating lipid redistribution, leading to excessive cardiac lipid uptake and lipotoxicity. Our study provides valuable insights into the cardiac effects of exercise in mice fed with HFCD, suggesting that counteracting the negative effect of HFCD by simultaneous physical exercise might be detrimental. Moreover, inappropriate physical exercise may damage certain organs even though it leads to weight loss and overall metabolic benefits. Of note, the current findings are based on animal experiments, the generalizability of these findings beyond this specific diet and mouse strain remains to be further explored.https://doi.org/10.1038/s41467-025-55917-8 |
| spellingShingle | Jing Geng Xiaoliang Zhang Yanjie Guo He Wen Dong Guo Qi Liang Siying Pu Ying Wang Mingchuan Liu Zhelong Li Wei Hu Xue Yang Pan Chang Lang Hu Yan Li Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice Nature Communications |
| title | Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice |
| title_full | Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice |
| title_fullStr | Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice |
| title_full_unstemmed | Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice |
| title_short | Moderate-intensity interval exercise exacerbates cardiac lipotoxicity in high-fat, high-calories diet-fed mice |
| title_sort | moderate intensity interval exercise exacerbates cardiac lipotoxicity in high fat high calories diet fed mice |
| url | https://doi.org/10.1038/s41467-025-55917-8 |
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