Rationale for Antioxidant Supplementation in Sarcopenia
Sarcopenia is an age-related clinical condition characterized by the progressive loss of motor units and wasting of muscle fibers resulting in decreased muscle function. The molecular mechanisms leading to sarcopenia are not completely identified, but the increased oxidative damage occurring in musc...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/316943 |
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| _version_ | 1832560772266328064 |
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| author | Francesco Cerullo Giovanni Gambassi Matteo Cesari |
| author_facet | Francesco Cerullo Giovanni Gambassi Matteo Cesari |
| author_sort | Francesco Cerullo |
| collection | DOAJ |
| description | Sarcopenia is an age-related clinical condition characterized by the progressive loss of motor units and wasting of muscle fibers resulting in decreased muscle function. The molecular mechanisms leading to sarcopenia are not completely identified, but the increased oxidative damage occurring in muscle cells during the course of aging represents one of the most accepted underlying pathways. In fact, skeletal muscle is a highly oxygenated tissue and the generation of reactive oxygen species is particularly enhanced in both contracting and at rest conditions. It has been suggested that oral antioxidant supplementation may contribute at reducing indices of oxidative stress both in animal and human models by reinforcing the natural endogenous defenses. Aim of the present paper is to discuss present evidence related to possible benefits of oral antioxidants in the prevention and treatment of sarcopenia. |
| format | Article |
| id | doaj-art-e77f1dab62924440a9833e29954c83e1 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-e77f1dab62924440a9833e29954c83e12025-02-03T01:26:49ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/316943316943Rationale for Antioxidant Supplementation in SarcopeniaFrancesco Cerullo0Giovanni Gambassi1Matteo Cesari2Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Roma, ItalyDipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Roma, ItalyInstitut du Vieillissement, Université de Toulouse, 31000 Toulouse, FranceSarcopenia is an age-related clinical condition characterized by the progressive loss of motor units and wasting of muscle fibers resulting in decreased muscle function. The molecular mechanisms leading to sarcopenia are not completely identified, but the increased oxidative damage occurring in muscle cells during the course of aging represents one of the most accepted underlying pathways. In fact, skeletal muscle is a highly oxygenated tissue and the generation of reactive oxygen species is particularly enhanced in both contracting and at rest conditions. It has been suggested that oral antioxidant supplementation may contribute at reducing indices of oxidative stress both in animal and human models by reinforcing the natural endogenous defenses. Aim of the present paper is to discuss present evidence related to possible benefits of oral antioxidants in the prevention and treatment of sarcopenia.http://dx.doi.org/10.1155/2012/316943 |
| spellingShingle | Francesco Cerullo Giovanni Gambassi Matteo Cesari Rationale for Antioxidant Supplementation in Sarcopenia Journal of Aging Research |
| title | Rationale for Antioxidant Supplementation in Sarcopenia |
| title_full | Rationale for Antioxidant Supplementation in Sarcopenia |
| title_fullStr | Rationale for Antioxidant Supplementation in Sarcopenia |
| title_full_unstemmed | Rationale for Antioxidant Supplementation in Sarcopenia |
| title_short | Rationale for Antioxidant Supplementation in Sarcopenia |
| title_sort | rationale for antioxidant supplementation in sarcopenia |
| url | http://dx.doi.org/10.1155/2012/316943 |
| work_keys_str_mv | AT francescocerullo rationaleforantioxidantsupplementationinsarcopenia AT giovannigambassi rationaleforantioxidantsupplementationinsarcopenia AT matteocesari rationaleforantioxidantsupplementationinsarcopenia |