NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION
Objective: Oral squamous cell carcinoma (OSCC) covers more than 90% of the malignant neoplasms in the mouth. It has been shown that angiotensin-converting enzyme (ACE) and paraoxonase (PON1) gene variants were associated with several cancers. Therefore, we investigated the possible association betwe...
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Istanbul University Press
2025-03-01
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| Series: | Sabiad |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA4666ACC1854A02808DCCBAFC394090 |
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| author | Ayşe Feyda Nursal Özge Gümüşay Serbülent Yiğit Nilüfer Kuruca Mehmet Kemal Tümer |
| author_facet | Ayşe Feyda Nursal Özge Gümüşay Serbülent Yiğit Nilüfer Kuruca Mehmet Kemal Tümer |
| author_sort | Ayşe Feyda Nursal |
| collection | DOAJ |
| description | Objective: Oral squamous cell carcinoma (OSCC) covers more than 90% of the malignant neoplasms in the mouth. It has been shown that angiotensin-converting enzyme (ACE) and paraoxonase (PON1) gene variants were associated with several cancers. Therefore, we investigated the possible association between ACE insertion/deletion (I/D)-PON1 L55M variants and OSCC development risk in a Turkish population. Material and Methods: A total of 155 people (104 healthy controls and 51 OSCC patients) made up the study population. These variants were genotyped using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) assays. Results: ACE I/D allele frequencies were significantly different between patients and controls. The ACE D allele was higher in the patient group compared to the control group, while the I allele was more prevalent in controls than patients (p˂0.0000001). When the patients and controls were examined based on the II+ID vs. DD genotype and II: ID vs. DD, a statistically significant correlation was found (p = 0.0000001 and p = 0.008691, respectively). The genotype and allele distribution of PON1 L55M did not significantly differ between the groups. Conclusion: In conclusion, our study showed that the ACE I/D variant D allele is a risk factor for the development of OSCC in Turkey. This study contributes to more studies to confirm that ACE I/D plays a role as a genetic risk factor for OSCC. |
| format | Article |
| id | doaj-art-e77a6828c8ca404ba8ad7b82c87d4b21 |
| institution | OA Journals |
| issn | 2651-4060 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Sabiad |
| spelling | doaj-art-e77a6828c8ca404ba8ad7b82c87d4b212025-08-20T02:27:31ZengIstanbul University PressSabiad2651-40602025-03-0181152010.26650/JARHS2025-1579437123456NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATIONAyşe Feyda Nursal0https://orcid.org/0000-0001-7639-1122Özge Gümüşay1https://orcid.org/0000-0002-6236-9829Serbülent Yiğit2https://orcid.org/0000-0002-1019-3964Nilüfer Kuruca3https://orcid.org/0000-0001-5601-4952Mehmet Kemal Tümer4https://orcid.org/0000-0002-6250-0954Hitit Üniversitesi, Çorum, TurkiyeTokat Gaziosmanpaşa Üniversitesi, Tokat, TurkiyeOndokuz Mayıs Üniversitesi, Samsun, TurkiyeOndokuz Mayıs Üniversitesi, Samsun, TurkiyeAlanya Alaaddin Keykubat Üniversitesi, Antalya, TurkiyeObjective: Oral squamous cell carcinoma (OSCC) covers more than 90% of the malignant neoplasms in the mouth. It has been shown that angiotensin-converting enzyme (ACE) and paraoxonase (PON1) gene variants were associated with several cancers. Therefore, we investigated the possible association between ACE insertion/deletion (I/D)-PON1 L55M variants and OSCC development risk in a Turkish population. Material and Methods: A total of 155 people (104 healthy controls and 51 OSCC patients) made up the study population. These variants were genotyped using polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) assays. Results: ACE I/D allele frequencies were significantly different between patients and controls. The ACE D allele was higher in the patient group compared to the control group, while the I allele was more prevalent in controls than patients (p˂0.0000001). When the patients and controls were examined based on the II+ID vs. DD genotype and II: ID vs. DD, a statistically significant correlation was found (p = 0.0000001 and p = 0.008691, respectively). The genotype and allele distribution of PON1 L55M did not significantly differ between the groups. Conclusion: In conclusion, our study showed that the ACE I/D variant D allele is a risk factor for the development of OSCC in Turkey. This study contributes to more studies to confirm that ACE I/D plays a role as a genetic risk factor for OSCC.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA4666ACC1854A02808DCCBAFC394090oral squamous cell carcinomaangiotensin-converting enzymeparaoxonasevariant |
| spellingShingle | Ayşe Feyda Nursal Özge Gümüşay Serbülent Yiğit Nilüfer Kuruca Mehmet Kemal Tümer NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION Sabiad oral squamous cell carcinoma angiotensin-converting enzyme paraoxonase variant |
| title | NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION |
| title_full | NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION |
| title_fullStr | NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION |
| title_full_unstemmed | NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION |
| title_short | NOT PON1 L55M BUT ACE I/D VARIANT MIGHT BE A RISK FACTOR FOR OSCC IN THE TURKISH POPULATION |
| title_sort | not pon1 l55m but ace i d variant might be a risk factor for oscc in the turkish population |
| topic | oral squamous cell carcinoma angiotensin-converting enzyme paraoxonase variant |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/CA4666ACC1854A02808DCCBAFC394090 |
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