Azadirachtin disrupts ecdysone signaling and alters sand fly immunity

Azadirachtin disrupts ecdysone signaling and alters sand fly immunity

Abstract Background Leishmaniasis is a group of neglected vector-borne diseases transmitted by phlebotomine sand flies. Leishmania parasites must overcome various defenses in the sand fly midgut, including the insects’s immune response. Insect immunity is regulated by the ecdysone hormone, which bin...

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Bibliographic Details
Main Authors: Cecilia Stahl Vieira, Sara Bisogno, Marco Salvemini, Erich Loza Telleria, Petr Volf
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Parasites & Vectors
Subjects:
Phlebotomus perniciosus
Azadirachtin
Ecdysone
Antimicrobial peptides
Online Access:https://doi.org/10.1186/s13071-024-06589-8
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