Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil
5-Fluorouracil (5-FU) is a chemotherapeutic agent frequently used for the treatment of solid tumors. In a few cases, 5-FU can be associated with coronary vasospasm, cardiac ischemia, or life-threatening arrhythmias. Recognition of 5-FU cardiotoxicity is clinically important as after the rapid sensat...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/4151474 |
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| author | Mariam Charkviani Natia Murvelashvili Francisco Barrera Alisha Sharma Randa Sharag Eldin Nur Un Nisa Nabil |
| author_facet | Mariam Charkviani Natia Murvelashvili Francisco Barrera Alisha Sharma Randa Sharag Eldin Nur Un Nisa Nabil |
| author_sort | Mariam Charkviani |
| collection | DOAJ |
| description | 5-Fluorouracil (5-FU) is a chemotherapeutic agent frequently used for the treatment of solid tumors. In a few cases, 5-FU can be associated with coronary vasospasm, cardiac ischemia, or life-threatening arrhythmias. Recognition of 5-FU cardiotoxicity is clinically important as after the rapid sensation of therapy, cardiotoxicity can be completely reversible, and on the other hand, readministration may lead to serious damage of the heart and even death. A 70-year-old male came to the emergency department (ED) with chest pain which started while receiving an infusion of 5-FU. The patient did not have a personal history or risk factors of coronary artery disease and his electrocardiogram (ECG) before starting chemotherapy was completely normal. In the ED, his ECG had ischemic changes, troponin was elevated, and echocardiogram showed anterior wall hypokinesis. However, emergent coronary angiogram did not reveal any acute coronary occlusion. 5-FU-induced cardiotoxicity was suspected; the patient was admitted to a progressive care unit for close monitoring and infusion of calcium channel blockers was initiated. The patient’s symptoms and ECG findings gradually resolved, and two days later on discharge, patient was chest pain free and ECG was normal. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications. |
| format | Article |
| id | doaj-art-e776140226f34c2bbf168dac36fc86aa |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-e776140226f34c2bbf168dac36fc86aa2025-02-03T01:01:27ZengWileyCase Reports in Oncological Medicine2090-67062090-67142020-01-01202010.1155/2020/41514744151474Rare Presentation of Cardiotoxicity Related to 5-FluorouracilMariam Charkviani0Natia Murvelashvili1Francisco Barrera2Alisha Sharma3Randa Sharag Eldin4Nur Un Nisa Nabil5Amita Saint Francis Hospital, Evanston, IL, USAAmita Saint Francis Hospital, Evanston, IL, USAAmita Saint Francis Hospital, Evanston, IL, USAAmita Saint Francis Hospital, Evanston, IL, USAAmita Saint Francis Hospital, Evanston, IL, USAAmita Saint Francis Hospital, Evanston, IL, USA5-Fluorouracil (5-FU) is a chemotherapeutic agent frequently used for the treatment of solid tumors. In a few cases, 5-FU can be associated with coronary vasospasm, cardiac ischemia, or life-threatening arrhythmias. Recognition of 5-FU cardiotoxicity is clinically important as after the rapid sensation of therapy, cardiotoxicity can be completely reversible, and on the other hand, readministration may lead to serious damage of the heart and even death. A 70-year-old male came to the emergency department (ED) with chest pain which started while receiving an infusion of 5-FU. The patient did not have a personal history or risk factors of coronary artery disease and his electrocardiogram (ECG) before starting chemotherapy was completely normal. In the ED, his ECG had ischemic changes, troponin was elevated, and echocardiogram showed anterior wall hypokinesis. However, emergent coronary angiogram did not reveal any acute coronary occlusion. 5-FU-induced cardiotoxicity was suspected; the patient was admitted to a progressive care unit for close monitoring and infusion of calcium channel blockers was initiated. The patient’s symptoms and ECG findings gradually resolved, and two days later on discharge, patient was chest pain free and ECG was normal. This case supports the vasospastic hypothesis of 5-FU cardiac toxicity, describes its clinical course, and emphasizes the importance of better awareness and early recognition of the rare side effect as it may allow physicians to reduce the risk of life-threatening complications.http://dx.doi.org/10.1155/2020/4151474 |
| spellingShingle | Mariam Charkviani Natia Murvelashvili Francisco Barrera Alisha Sharma Randa Sharag Eldin Nur Un Nisa Nabil Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil Case Reports in Oncological Medicine |
| title | Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil |
| title_full | Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil |
| title_fullStr | Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil |
| title_full_unstemmed | Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil |
| title_short | Rare Presentation of Cardiotoxicity Related to 5-Fluorouracil |
| title_sort | rare presentation of cardiotoxicity related to 5 fluorouracil |
| url | http://dx.doi.org/10.1155/2020/4151474 |
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