Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma

Tumor-derived exosomal CCT6A serves as a matchmaker introducing chemokines to tumor-associated macrophages in pancreatic ductal adenocarcinoma

Abstract M2-polarized tumor-associated macrophages (TAMs) are a key factor contributing to the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). While various factors within the tumor microenvironment (TME) drive their formation, the role of PDAC-derived exosomes in this process remains unc...

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Main Authors: Tianyin Ma, Wing-Wa Guo, Minghe Zhang, Wenzhi He, Cairang Dongzhi, Xiangdong Gongye, Peng Xia, Yibo Chai, Zhang Chen, Yimin Zhu, Chengming Qu, Jie Liu, Zhiyong Yang, Weijie Ma, Ming Tian, Yufeng Yuan
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07720-y
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