Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study
The study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enr...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8481049 |
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| author | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuting Chen Yuhang Ma Yanhua Yin Yong Wu Yaqiong Jin Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng |
| author_facet | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuting Chen Yuhang Ma Yanhua Yin Yong Wu Yaqiong Jin Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng |
| author_sort | Xiaoying Ding |
| collection | DOAJ |
| description | The study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enrolled in this study. Anthropometric, biochemical, thyroid ultrasonographic, and other metabolic parameters were all measured. There was obviously sexual difference in the prevalence of TN (males 26.0%, females 38.5%, resp.). The prevalence of TN in hyperuricemia (45.7% versus 37.4%, P = 0.001), NAFLD (41.2% versus 36.4%, P < 0.05), and MetS (41.4% versus 35.4%, P < 0.001) groups was significantly increased only in females. Insulin resistance [OR = 1.31 (1.15, 1.49)], MetS [OR = 1.18 (1.03, 1.35)], and diabetes [OR = 1.25 (1.06, 1.48)] were all independent risk factors for TN in total subjects, whereas, after stratified analysis of gender, MetS [OR = 1.29, (1.09, 1.53)] and diabetes [OR = 1.47, (1.17, 1.84)] are still strongly and independently associated with the higher risks of TN in female subjects, but not in males. Our results suggest that the components of MetS might associate with the higher risks of TN in women than in men, but further cohort study of this gender disparity in the association between TN and MetS is required. |
| format | Article |
| id | doaj-art-e758efd1fb6a4034a2ad01598bea76b0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e758efd1fb6a4034a2ad01598bea76b02025-02-03T01:24:20ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/84810498481049Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based StudyXiaoying Ding0Ying Xu1Yufan Wang2Xiaohua Li3Chunhua Lu4Jing Su5Yuting Chen6Yuhang Ma7Yanhua Yin8Yong Wu9Yaqiong Jin10Lihua Yu11Junyi Jiang12Naisi Zhao13Qingwu Yan14Andrew S. Greenberg15Haiyan Sun16Mingyu Gu17Li Zhao18Yunhong Huang19Yijie Wu20Chunxian Qian21Yongde Peng22Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Chronic Disease Prevention and Control, Sijing Community Health Service Centre of Songjiang District, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, Shanghai 201601, ChinaDepartment of Internal Medicine, Sijing Hospital, Shanghai 201601, ChinaDepartment of Chronic Disease Prevention and Control, Sijing Community Health Service Centre of Songjiang District, Shanghai 201601, ChinaShanghai Pudong New Area Center for Disease Control and Prevention, Shanghai 200136, ChinaDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USAJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USAJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USADepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Internal Medicine, Sijing Hospital, Shanghai 201601, ChinaDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaThe study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enrolled in this study. Anthropometric, biochemical, thyroid ultrasonographic, and other metabolic parameters were all measured. There was obviously sexual difference in the prevalence of TN (males 26.0%, females 38.5%, resp.). The prevalence of TN in hyperuricemia (45.7% versus 37.4%, P = 0.001), NAFLD (41.2% versus 36.4%, P < 0.05), and MetS (41.4% versus 35.4%, P < 0.001) groups was significantly increased only in females. Insulin resistance [OR = 1.31 (1.15, 1.49)], MetS [OR = 1.18 (1.03, 1.35)], and diabetes [OR = 1.25 (1.06, 1.48)] were all independent risk factors for TN in total subjects, whereas, after stratified analysis of gender, MetS [OR = 1.29, (1.09, 1.53)] and diabetes [OR = 1.47, (1.17, 1.84)] are still strongly and independently associated with the higher risks of TN in female subjects, but not in males. Our results suggest that the components of MetS might associate with the higher risks of TN in women than in men, but further cohort study of this gender disparity in the association between TN and MetS is required.http://dx.doi.org/10.1155/2017/8481049 |
| spellingShingle | Xiaoying Ding Ying Xu Yufan Wang Xiaohua Li Chunhua Lu Jing Su Yuting Chen Yuhang Ma Yanhua Yin Yong Wu Yaqiong Jin Lihua Yu Junyi Jiang Naisi Zhao Qingwu Yan Andrew S. Greenberg Haiyan Sun Mingyu Gu Li Zhao Yunhong Huang Yijie Wu Chunxian Qian Yongde Peng Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study Mediators of Inflammation |
| title | Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study |
| title_full | Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study |
| title_fullStr | Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study |
| title_full_unstemmed | Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study |
| title_short | Gender Disparity in the Relationship between Prevalence of Thyroid Nodules and Metabolic Syndrome Components: The SHDC-CDPC Community-Based Study |
| title_sort | gender disparity in the relationship between prevalence of thyroid nodules and metabolic syndrome components the shdc cdpc community based study |
| url | http://dx.doi.org/10.1155/2017/8481049 |
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