Drug retention after intradiscal administration

Drug retention after intradiscal administration

Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release...

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Bibliographic Details
Main Authors: Imke Rudnik-Jansen, Jie Du, Nina Karssemakers-Degen, Anna R. Tellegen, Parvesh Wadhwani, Daniele Zuncheddu, Björn P. Meij, Jens Thies, Pieter Emans, Fetullah C. Öner, George Mihov, Joao Pedro Garcia, Anne S. Ulrich, Sibylle Grad, Marianna A. Tryfonidou, Hugo van Ingen, Laura B. Creemers
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Drug Delivery
Subjects:
Drug retention
peptide
small molecule
polyester amide microsphere
intervertebral disk degeneration
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2024.2415579
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