Biochemical and Functional Characterization of <i>E. coli</i> Aminopeptidase N: A New Role as a 6-Monoacetylmorphine Hydrolase

Biochemical and Functional Characterization of <i>E. coli</i> Aminopeptidase N: A New Role as a 6-Monoacetylmorphine Hydrolase

6-monoacetylmorphine (6-MAM), a primary active metabolite of heroin that reaches the human brain, plays a crucial role in producing heroin-associated physiological and lethal effects. Therefore, 6-MAM has emerged as a key target for alleviating the adverse consequences of heroin abuse. In this study...

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Bibliographic Details
Main Authors: Xiabin Chen, Yishuang Li, Jianzhuang Yao, Xiaoxuan Li, Hualing Li, Zelin Wu, Qi Hu, Nuo Xu, Tingjun Hou, Jiye Wang, Shurong Hou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
<i>Escherichia coli</i> aminopeptidase N
heroin and 6-MAM
biochemical property
catalytic function
Online Access:https://www.mdpi.com/2218-273X/15/6/822
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