Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat
Abstract Irrational application and overuse of antibiotics in poultry production is associated with antibiotic residues in meat tissues which lead to the development of antibiotic resistance in pathogenic bacteria such as Salmonella. This study investigated the co-existence of multi-drug resistant S...
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Nature Portfolio
2025-04-01
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| Online Access: | https://doi.org/10.1038/s41598-025-98189-4 |
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| author | Hala R. Ali Esraa G. Hefny Naglaa F. Koraney Samah F. Ali Mohamed I. AbdAllah Mai A. Fadel Sara M. Elnomrosy Momataz A. Shahein |
| author_facet | Hala R. Ali Esraa G. Hefny Naglaa F. Koraney Samah F. Ali Mohamed I. AbdAllah Mai A. Fadel Sara M. Elnomrosy Momataz A. Shahein |
| author_sort | Hala R. Ali |
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| description | Abstract Irrational application and overuse of antibiotics in poultry production is associated with antibiotic residues in meat tissues which lead to the development of antibiotic resistance in pathogenic bacteria such as Salmonella. This study investigated the co-existence of multi-drug resistant Salmonella typhimurium (S. typhimurium) and residual traces of antibiotics in chilled chicken meat collected from Fayoum province in Egypt. Our data reported that 22.2% of chicken meat and liver were contaminated with S. typhimurium with 100% being drug resistant to a wide range of antimicrobials including tylosin, chloramphenicol, and oxytetracycline (OTC). The residual analysis of chicken meat samples revealed that they contained residues of 3antibacterial drugs including tylosin, chloramphenicol, OTC and its metabolite (4-epi-OTC). The statistical analysis of obtained data also revealed a relationship between S. typhimurium resistance and the presence of antibiotic residues in chicken samples, as isolates derived from samples with residual drug content higher than maximum residue levels (MRL) were found to be resistant to the same antibiotic. This confirms the importance of integrating sustainable practices in the veterinary field with a strict commitment to monitoring the bacterial content and residual antibiotics in foods of animal origin before marketing them, to protect the effectiveness of antibiotics for future generations. |
| format | Article |
| id | doaj-art-e73e2ce1ea274658bde6e77756adfd21 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-e73e2ce1ea274658bde6e77756adfd212025-08-20T01:47:33ZengNature PortfolioScientific Reports2045-23222025-04-0115111210.1038/s41598-025-98189-4Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meatHala R. Ali0Esraa G. Hefny1Naglaa F. Koraney2Samah F. Ali3Mohamed I. AbdAllah4Mai A. Fadel5Sara M. Elnomrosy6Momataz A. Shahein7Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Centre (ARC)Food Hygiene Department, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC)Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Centre (ARC)Bacteriology Department, Animal Health Research Institute (AHRI), Agriculture Research Centre (ARC)Genome Research Unit, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC)Pharmacology and Pyrogen Unit, Department of Biochemistry, Toxicology and Feed Deficiency, Animal Health Research Institute (AHRI), Agricultural Research Center (ARC)Genome Research Unit, Animal Health Research Institute (AHRI), Agriculture Research Center (ARC)Department of Virology Research, Animal Health Research Institute, Agriculture Research Center (ARC)Abstract Irrational application and overuse of antibiotics in poultry production is associated with antibiotic residues in meat tissues which lead to the development of antibiotic resistance in pathogenic bacteria such as Salmonella. This study investigated the co-existence of multi-drug resistant Salmonella typhimurium (S. typhimurium) and residual traces of antibiotics in chilled chicken meat collected from Fayoum province in Egypt. Our data reported that 22.2% of chicken meat and liver were contaminated with S. typhimurium with 100% being drug resistant to a wide range of antimicrobials including tylosin, chloramphenicol, and oxytetracycline (OTC). The residual analysis of chicken meat samples revealed that they contained residues of 3antibacterial drugs including tylosin, chloramphenicol, OTC and its metabolite (4-epi-OTC). The statistical analysis of obtained data also revealed a relationship between S. typhimurium resistance and the presence of antibiotic residues in chicken samples, as isolates derived from samples with residual drug content higher than maximum residue levels (MRL) were found to be resistant to the same antibiotic. This confirms the importance of integrating sustainable practices in the veterinary field with a strict commitment to monitoring the bacterial content and residual antibiotics in foods of animal origin before marketing them, to protect the effectiveness of antibiotics for future generations.https://doi.org/10.1038/s41598-025-98189-4SalmonellaS. typhimuriumAntimicrobialsAntibiotic residues |
| spellingShingle | Hala R. Ali Esraa G. Hefny Naglaa F. Koraney Samah F. Ali Mohamed I. AbdAllah Mai A. Fadel Sara M. Elnomrosy Momataz A. Shahein Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat Scientific Reports Salmonella S. typhimurium Antimicrobials Antibiotic residues |
| title | Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat |
| title_full | Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat |
| title_fullStr | Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat |
| title_full_unstemmed | Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat |
| title_short | Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat |
| title_sort | antibiotic residues correlate with antibiotic resistance of salmonella typhimurium isolated from edible chicken meat |
| topic | Salmonella S. typhimurium Antimicrobials Antibiotic residues |
| url | https://doi.org/10.1038/s41598-025-98189-4 |
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