Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics
This study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma. Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal downregulation of the fatty ac...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2021/8842105 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467480819367936 |
|---|---|
| author | Ping Wu Yingkun Xu Jiayi Li Xiaowei Li Peizhi Zhang Ningke Ruan Cong Zhang Panpan Sun Qifei Wang Guangzhen Wu |
| author_facet | Ping Wu Yingkun Xu Jiayi Li Xiaowei Li Peizhi Zhang Ningke Ruan Cong Zhang Panpan Sun Qifei Wang Guangzhen Wu |
| author_sort | Ping Wu |
| collection | DOAJ |
| description | This study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma. Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal downregulation of the fatty acid metabolism pathway occurred in all three renal cell carcinoma subtypes. Alteration of the fatty acid metabolism pathway was vital in the development of pan-renal cell carcinoma. Bioinformatics methods were used to obtain a panoramic view of copy number variation, single-nucleotide variation, mRNA expression, and the survival landscape of fatty acid metabolism pathway-related genes in pan-renal cell carcinoma. Most importantly, we used genes related to the fatty acid metabolism pathway to establish a prognostic-related risk model in the three subtypes of renal cell carcinoma. The data will be valuable for future clinical treatment and scientific research. |
| format | Article |
| id | doaj-art-e7343a8b6c8644e79a2f3b20e738d4a2 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-e7343a8b6c8644e79a2f3b20e738d4a22025-08-20T03:26:14ZengWileyAnalytical Cellular Pathology2210-71772210-71852021-01-01202110.1155/2021/88421058842105Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from BioinformaticsPing Wu0Yingkun Xu1Jiayi Li2Xiaowei Li3Peizhi Zhang4Ningke Ruan5Cong Zhang6Panpan Sun7Qifei Wang8Guangzhen Wu9Department of Anesthesiology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Business, Hanyang University, Seoul, Republic of KoreaDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Urology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaThe Nursing College of Zhengzhou University, Zhengzhou, ChinaDepartment of Pain Management, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Pain Management, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, ChinaThis study analyzed and compared the potential role of fatty acid metabolism pathways in three subtypes of renal cell carcinoma. Biological pathways that were abnormally up- and downregulated were identified through gene set variation analysis in the subtypes. Abnormal downregulation of the fatty acid metabolism pathway occurred in all three renal cell carcinoma subtypes. Alteration of the fatty acid metabolism pathway was vital in the development of pan-renal cell carcinoma. Bioinformatics methods were used to obtain a panoramic view of copy number variation, single-nucleotide variation, mRNA expression, and the survival landscape of fatty acid metabolism pathway-related genes in pan-renal cell carcinoma. Most importantly, we used genes related to the fatty acid metabolism pathway to establish a prognostic-related risk model in the three subtypes of renal cell carcinoma. The data will be valuable for future clinical treatment and scientific research.http://dx.doi.org/10.1155/2021/8842105 |
| spellingShingle | Ping Wu Yingkun Xu Jiayi Li Xiaowei Li Peizhi Zhang Ningke Ruan Cong Zhang Panpan Sun Qifei Wang Guangzhen Wu Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics Analytical Cellular Pathology |
| title | Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics |
| title_full | Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics |
| title_fullStr | Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics |
| title_full_unstemmed | Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics |
| title_short | Comparison of the Fatty Acid Metabolism Pathway in Pan-Renal Cell Carcinoma: Evidence from Bioinformatics |
| title_sort | comparison of the fatty acid metabolism pathway in pan renal cell carcinoma evidence from bioinformatics |
| url | http://dx.doi.org/10.1155/2021/8842105 |
| work_keys_str_mv | AT pingwu comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT yingkunxu comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT jiayili comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT xiaoweili comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT peizhizhang comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT ningkeruan comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT congzhang comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT panpansun comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT qifeiwang comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics AT guangzhenwu comparisonofthefattyacidmetabolismpathwayinpanrenalcellcarcinomaevidencefrombioinformatics |