Anemia and retinopathy of prematurity: A narrative review
ABSTRACT Retinopathy of prematurity (ROP) and anemia are often comorbid in preterm and low birth weight infants in the United States. However, the relationship between ROP and anemia in infants is unclear across prospective and retrospective studies due to confounding from other comorbidities of pre...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | Pediatric Investigation |
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| Online Access: | https://doi.org/10.1002/ped4.12468 |
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| author | Minali Prasad David Dombrovsky Stephen P. Christiansen Ellen C. Ingolfsland |
| author_facet | Minali Prasad David Dombrovsky Stephen P. Christiansen Ellen C. Ingolfsland |
| author_sort | Minali Prasad |
| collection | DOAJ |
| description | ABSTRACT Retinopathy of prematurity (ROP) and anemia are often comorbid in preterm and low birth weight infants in the United States. However, the relationship between ROP and anemia in infants is unclear across prospective and retrospective studies due to confounding from other comorbidities of prematurity and variable study designs. Molecular mechanisms that may underlie this association include tissue hypoxia, oxidative stress, inflammation, and the timing of onset of anemia relative to the phase of ROP. Furthermore, maternal or neonatal disruptions in iron homeostasis, leading to either iron deficiency or accumulation, have been associated with ROP. Further studies, including randomized clinical trials, are needed to better elucidate the association between ROP and anemia, as well as the impact of the timing of the onset of anemia. |
| format | Article |
| id | doaj-art-e730f9f9237b4fa3bb74732b85fda5f0 |
| institution | DOAJ |
| issn | 2574-2272 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pediatric Investigation |
| spelling | doaj-art-e730f9f9237b4fa3bb74732b85fda5f02025-08-20T03:22:09ZengWileyPediatric Investigation2574-22722025-06-019212513210.1002/ped4.12468Anemia and retinopathy of prematurity: A narrative reviewMinali Prasad0David Dombrovsky1Stephen P. Christiansen2Ellen C. Ingolfsland3Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USADepartment of Biology Union College Schenectady New York USADepartment of Ophthalmology Boston Medical Center Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USADepartment of Pediatrics Division of Neonatology University of Minnesota Minneapolis Minnesota USAABSTRACT Retinopathy of prematurity (ROP) and anemia are often comorbid in preterm and low birth weight infants in the United States. However, the relationship between ROP and anemia in infants is unclear across prospective and retrospective studies due to confounding from other comorbidities of prematurity and variable study designs. Molecular mechanisms that may underlie this association include tissue hypoxia, oxidative stress, inflammation, and the timing of onset of anemia relative to the phase of ROP. Furthermore, maternal or neonatal disruptions in iron homeostasis, leading to either iron deficiency or accumulation, have been associated with ROP. Further studies, including randomized clinical trials, are needed to better elucidate the association between ROP and anemia, as well as the impact of the timing of the onset of anemia.https://doi.org/10.1002/ped4.12468AnemiaIron homeostasisRetinopathy of prematurity |
| spellingShingle | Minali Prasad David Dombrovsky Stephen P. Christiansen Ellen C. Ingolfsland Anemia and retinopathy of prematurity: A narrative review Pediatric Investigation Anemia Iron homeostasis Retinopathy of prematurity |
| title | Anemia and retinopathy of prematurity: A narrative review |
| title_full | Anemia and retinopathy of prematurity: A narrative review |
| title_fullStr | Anemia and retinopathy of prematurity: A narrative review |
| title_full_unstemmed | Anemia and retinopathy of prematurity: A narrative review |
| title_short | Anemia and retinopathy of prematurity: A narrative review |
| title_sort | anemia and retinopathy of prematurity a narrative review |
| topic | Anemia Iron homeostasis Retinopathy of prematurity |
| url | https://doi.org/10.1002/ped4.12468 |
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