Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats
We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnata...
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| Format: | Article |
| Language: | English |
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Wiley
1995-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S096293519500069X |
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| author | M. R. Pierce C. A. Voelker I. R. S. Sosenko S. Bustamante S. M. Olister X.-J. Zhang D. A. Clark M. J. S. Miller |
| author_facet | M. R. Pierce C. A. Voelker I. R. S. Sosenko S. Bustamante S. M. Olister X.-J. Zhang D. A. Clark M. J. S. Miller |
| author_sort | M. R. Pierce |
| collection | DOAJ |
| description | We evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnatal exposure to hyperoxia (>95% O2) or room air. The survival rate of L-NAME treated pups when placed in > 95% O2 at birth was significantly lower than controls from day 4 (L-NAME, 87%; control pups, 100%, p < 0.05) to 14 (L-NAME, 0%; control pups, 53%, p < 0.05). Foetal pulmonary artery vasoconstriction was induced by L-NAME with a decrease in internal diameter from 0.88 ± 0.03 mm to 0.64 ± 0.01 mm in control vs. L-NAME groups (p < 0.05), respectively. We conclude that perinatal NOS inhibition results in pulmonary artery vasoconstriction and a decreased tolerance to hyperoxia induced lung injury in newborn rats. |
| format | Article |
| id | doaj-art-e72fe76112dd4fd88adba094f7fa07cc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e72fe76112dd4fd88adba094f7fa07cc2025-02-03T05:59:55ZengWileyMediators of Inflammation0962-93511466-18611995-01-014643143610.1155/S096293519500069XNitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn ratsM. R. Pierce0C. A. Voelker1I. R. S. Sosenko2S. Bustamante3S. M. Olister4X.-J. Zhang5D. A. Clark6M. J. S. Miller7Department of Pediatrics, Tulane Medical Center, New Orleans, LA, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Pediatrics, University of Miami Medical Center, Miami, FL, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USADepartment of Pediatrics, Louisiana State University Medical Center, New Orleans, LA, USAWe evaluated the effects of sustained perinatal inhibition of NO synthase (NOS) on hyperoxia induced lung injury in newborn rats. NG-nitro-Larginine-methyl-ester (L-NAME) or untreated water was administered to pregnant rats for the final 7 days of gestation and during lactation; followed by postnatal exposure to hyperoxia (>95% O2) or room air. The survival rate of L-NAME treated pups when placed in > 95% O2 at birth was significantly lower than controls from day 4 (L-NAME, 87%; control pups, 100%, p < 0.05) to 14 (L-NAME, 0%; control pups, 53%, p < 0.05). Foetal pulmonary artery vasoconstriction was induced by L-NAME with a decrease in internal diameter from 0.88 ± 0.03 mm to 0.64 ± 0.01 mm in control vs. L-NAME groups (p < 0.05), respectively. We conclude that perinatal NOS inhibition results in pulmonary artery vasoconstriction and a decreased tolerance to hyperoxia induced lung injury in newborn rats.http://dx.doi.org/10.1155/S096293519500069X |
| spellingShingle | M. R. Pierce C. A. Voelker I. R. S. Sosenko S. Bustamante S. M. Olister X.-J. Zhang D. A. Clark M. J. S. Miller Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats Mediators of Inflammation |
| title | Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| title_full | Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| title_fullStr | Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| title_full_unstemmed | Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| title_short | Nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| title_sort | nitric oxide synthase inhibition decreases tolerance to hyperoxia in newborn rats |
| url | http://dx.doi.org/10.1155/S096293519500069X |
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