The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study)
Objective: Epidemiological studies show that recently there has been an increase in the number of cerebrovascular diseases and the mortality rate among the population. This trend is associated with a changing of metabolic processes in the body, in particular lipid metabolism, caused by an unbalanced...
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| Format: | Article |
| Language: | English |
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Center for Scientific Research and Development of Education.
2024-12-01
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| Series: | Heart Vessels and Transplantation |
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| Online Access: | http://hvt-journal.com/articles/art527 |
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| author | Aigul T. Altynbekova Elmira M. Mamytova Yusuf Kh-M Shidakov Aicholpon T. Israilova Bolotbek Alymjan ulu Rustam R. Tuhvatshin |
| author_facet | Aigul T. Altynbekova Elmira M. Mamytova Yusuf Kh-M Shidakov Aicholpon T. Israilova Bolotbek Alymjan ulu Rustam R. Tuhvatshin |
| author_sort | Aigul T. Altynbekova |
| collection | DOAJ |
| description | Objective: Epidemiological studies show that recently there has been an increase in the number of cerebrovascular diseases and the mortality rate among the population. This trend is associated with a changing of metabolic processes in the body, in particular lipid metabolism, caused by an unbalanced high-calorie diet.
The aim of the study was to investigate the effect of an isolated fat diet on lactate blood level and histomorphological changes in microcirculation of the rats` brain.
Methods: The design of the study is experimental randomized. The study was conducted on sexually mature 7-8 months old lineal Wistar male rats, which were randomly divided into 2 groups – control (n=10) and experimental (n=9). The rats of the experimental group 1 ("isolated fat diet") were fed a diet consisting of fat-tailed sheep for 30 days. The control group was on a standard vivarium diet. Animal weight gain, serum lactate levels and histomorphological changes in the blood vessels of the brain regions of experimental animals were observed. Statistical processing of the results was carried out using the t-test for independent and paired samples.
Results: No increase in total weight was observed in the animals of the experimental group, on the contrary, weight loss in rats was noted (p<0.001). During the experiment, a 2.1-fold increase in lactate levels was verified in animals of the experimental group (p<0.001). An unbalanced diet led to a number of pathological changes of the structural integrity of the wall of the microvessels of the rat brain, which promoted a slowdown in blood flow and blood cells aggregation and, ultimately lead to the development of blood clots.
Conclusion: The obtained experimental data show changes in lipid metabolism and vascular remodeling of the microcirculatory bed of the rat brain due to increased fat intake. |
| format | Article |
| id | doaj-art-e72aeac8f9d5416dad2d90f9cc79fe21 |
| institution | OA Journals |
| issn | 1694-7886 1694-7894 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Center for Scientific Research and Development of Education. |
| record_format | Article |
| series | Heart Vessels and Transplantation |
| spelling | doaj-art-e72aeac8f9d5416dad2d90f9cc79fe212025-08-20T01:58:56ZengCenter for Scientific Research and Development of Education.Heart Vessels and Transplantation1694-78861694-78942024-12-018410.24969/hvt.2024.527The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study)Aigul T. Altynbekova0https://orcid.org/0009-0000-8929-6929Elmira M. Mamytova1https://orcid.org/0000-0002-4322-5555Yusuf Kh-M Shidakov2https://orcid.org/0000-0002-2779-5574Aicholpon T. Israilova3https://orcid.org/0009-0004-7373-5814Bolotbek Alymjan ulu4https://orcid.org/0000-0001-9082-7279Rustam R. Tuhvatshin5https://orcid.org/0000-0002-9329-8568NAO "National Center for Child Rehabilitation", Astana, Republic of Kazakhstan Department of Neurologyand Clinical Genetics, Kyrgyz State Medical Academy named after I. K. Akhunbayev, Bishkek, Kyrgyz RepublicKyrgyz-Russian Slavic University named after B. N. Yeltsin, Bishkek, Kyrgyz RepublicDepartment of Neurologyand Clinical Genetics, Kyrgyz State Medical Academy named after I. K. Akhunbayev, Bishkek, Kyrgyz Republic; Kyrgyz-Russian Slavic University named after B. N. Yeltsin, Bishkek, Kyrgyz RepublicDepartment of Neurologyand Clinical Genetics, Kyrgyz State Medical Academy named after I. K. Akhunbayev, Bishkek, Kyrgyz RepublicDepartment of Pathological Physiology, Kyrgyz State Medical Academy named after I. K. Akhunbayev, Bishkek, Kyrgyz Republic Objective: Epidemiological studies show that recently there has been an increase in the number of cerebrovascular diseases and the mortality rate among the population. This trend is associated with a changing of metabolic processes in the body, in particular lipid metabolism, caused by an unbalanced high-calorie diet. The aim of the study was to investigate the effect of an isolated fat diet on lactate blood level and histomorphological changes in microcirculation of the rats` brain. Methods: The design of the study is experimental randomized. The study was conducted on sexually mature 7-8 months old lineal Wistar male rats, which were randomly divided into 2 groups – control (n=10) and experimental (n=9). The rats of the experimental group 1 ("isolated fat diet") were fed a diet consisting of fat-tailed sheep for 30 days. The control group was on a standard vivarium diet. Animal weight gain, serum lactate levels and histomorphological changes in the blood vessels of the brain regions of experimental animals were observed. Statistical processing of the results was carried out using the t-test for independent and paired samples. Results: No increase in total weight was observed in the animals of the experimental group, on the contrary, weight loss in rats was noted (p<0.001). During the experiment, a 2.1-fold increase in lactate levels was verified in animals of the experimental group (p<0.001). An unbalanced diet led to a number of pathological changes of the structural integrity of the wall of the microvessels of the rat brain, which promoted a slowdown in blood flow and blood cells aggregation and, ultimately lead to the development of blood clots. Conclusion: The obtained experimental data show changes in lipid metabolism and vascular remodeling of the microcirculatory bed of the rat brain due to increased fat intake.http://hvt-journal.com/articles/art527high-fat dietratsblood vesselsbrainmicrovascular circulationlactate. |
| spellingShingle | Aigul T. Altynbekova Elmira M. Mamytova Yusuf Kh-M Shidakov Aicholpon T. Israilova Bolotbek Alymjan ulu Rustam R. Tuhvatshin The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) Heart Vessels and Transplantation high-fat diet rats blood vessels brain microvascular circulation lactate. |
| title | The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) |
| title_full | The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) |
| title_fullStr | The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) |
| title_full_unstemmed | The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) |
| title_short | The effect of an isolated fat diet on the blood vessels of the rat´s brain (experimental randomized study) |
| title_sort | effect of an isolated fat diet on the blood vessels of the rat´s brain experimental randomized study |
| topic | high-fat diet rats blood vessels brain microvascular circulation lactate. |
| url | http://hvt-journal.com/articles/art527 |
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