Development and validation of an LC-MS/MS method for highly concentrated tacrolimus and cyclosporine samples prepared from pharmaceutical products to assess drug loss from feeding tubes

Development and validation of an LC-MS/MS method for highly concentrated tacrolimus and cyclosporine samples prepared from pharmaceutical products to assess drug loss from feeding tubes

Introduction: Tacrolimus and cyclosporine are common immunosuppressants utilized post-organ transplantation to manage allograft rejection. Both have narrow therapeutic indices and are frequently measured to support dose adjustments. Although nasogastric tubes are commonly used to provide nutritional...

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Bibliographic Details
Main Authors: Yi Xiao, Mari Ishak Gabra, Edward Leung
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Subjects:
NG tubes
Immunosuppressants
LC-MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X24000312
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