Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study
Introduction: Compartment model analysis of diffusion MRI data provides unique information on the microstructural properties of white matter. However, studies relating compartment model microstructural measures to longitudinal cardiometabolic health data are rare. Methods: 130 cognitively healthy pa...
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Elsevier
2025-02-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925000369 |
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| author | Reagan Dugan Sreekrishna Ramakrishnapillai Julia St Amant Kori Murray Kevin McKlveen Maryam Naseri Kaitlyn Madden Lydia Bazzano Owen Carmichael |
| author_facet | Reagan Dugan Sreekrishna Ramakrishnapillai Julia St Amant Kori Murray Kevin McKlveen Maryam Naseri Kaitlyn Madden Lydia Bazzano Owen Carmichael |
| author_sort | Reagan Dugan |
| collection | DOAJ |
| description | Introduction: Compartment model analysis of diffusion MRI data provides unique information on the microstructural properties of white matter. However, studies relating compartment model microstructural measures to longitudinal cardiometabolic health data are rare. Methods: 130 cognitively healthy participants in the Bogalusa Heart Study completed diffusion MRI scans. Compartment model analysis was performed, and summary metrics were measured in organized and diffuse white matter. Multiple linear regression models were used to relate the white matter microstructure metrics to demographics and cardiometabolic risk factors. Results: In both organized and diffuse white matter, age was associated with worse diffusion metrics, women had better diffusion metrics than men, and African American participants had worse diffusion metrics compared to White participants. Greater blood pressure in pre-adulthood was associated with worse diffusion metrics in midlife. Discussion: Summary metrics from compartment model analyses of diffusion MRI data were associated cardiometabolic risk factors from youth to midlife as well as demographic factors. |
| format | Article |
| id | doaj-art-e7219cef1ddf4a32b00bbf0eadea7afc |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-e7219cef1ddf4a32b00bbf0eadea7afc2025-02-06T05:11:08ZengElsevierNeuroImage1095-95722025-02-01307121034Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart StudyReagan Dugan0Sreekrishna Ramakrishnapillai1Julia St Amant2Kori Murray3Kevin McKlveen4Maryam Naseri5Kaitlyn Madden6Lydia Bazzano7Owen Carmichael8Department of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA; Corresponding author at: Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop St suite b-400, Pittsburgh, PA, 15213, USAPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USAPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USAPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USADepartment of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USAPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USADepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA, 70112, USAPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USAIntroduction: Compartment model analysis of diffusion MRI data provides unique information on the microstructural properties of white matter. However, studies relating compartment model microstructural measures to longitudinal cardiometabolic health data are rare. Methods: 130 cognitively healthy participants in the Bogalusa Heart Study completed diffusion MRI scans. Compartment model analysis was performed, and summary metrics were measured in organized and diffuse white matter. Multiple linear regression models were used to relate the white matter microstructure metrics to demographics and cardiometabolic risk factors. Results: In both organized and diffuse white matter, age was associated with worse diffusion metrics, women had better diffusion metrics than men, and African American participants had worse diffusion metrics compared to White participants. Greater blood pressure in pre-adulthood was associated with worse diffusion metrics in midlife. Discussion: Summary metrics from compartment model analyses of diffusion MRI data were associated cardiometabolic risk factors from youth to midlife as well as demographic factors.http://www.sciencedirect.com/science/article/pii/S1053811925000369Diffusion MRICompartment modelMicrostructureBlood pressureWhite matterNeurite density |
| spellingShingle | Reagan Dugan Sreekrishna Ramakrishnapillai Julia St Amant Kori Murray Kevin McKlveen Maryam Naseri Kaitlyn Madden Lydia Bazzano Owen Carmichael Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study NeuroImage Diffusion MRI Compartment model Microstructure Blood pressure White matter Neurite density |
| title | Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study |
| title_full | Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study |
| title_fullStr | Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study |
| title_full_unstemmed | Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study |
| title_short | Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study |
| title_sort | lifespan cardiometabolic exposures are associated with midlife white matter microstructure the bogalusa heart study |
| topic | Diffusion MRI Compartment model Microstructure Blood pressure White matter Neurite density |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925000369 |
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