Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid

A previously well 32-year-old Chinese male presented with acute bilateral upper and lower limb paralysis upon waking, ten days after the onset of COVID-19 infection. Examination revealed areflexia over all four limbs, associated with reduced muscle strength, but no sensory or cranial nerve deficit....

Full description

Saved in:
Bibliographic Details
Main Authors: Sarah Ying Tse Tan, Jiaqing Xiong, Troy H Puar, Joan Khoo, Andy Jun-wei Wong, Shui Boon Soh
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2022/5827664
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832545610449813504
author Sarah Ying Tse Tan
Jiaqing Xiong
Troy H Puar
Joan Khoo
Andy Jun-wei Wong
Shui Boon Soh
author_facet Sarah Ying Tse Tan
Jiaqing Xiong
Troy H Puar
Joan Khoo
Andy Jun-wei Wong
Shui Boon Soh
author_sort Sarah Ying Tse Tan
collection DOAJ
description A previously well 32-year-old Chinese male presented with acute bilateral upper and lower limb paralysis upon waking, ten days after the onset of COVID-19 infection. Examination revealed areflexia over all four limbs, associated with reduced muscle strength, but no sensory or cranial nerve deficit. Initial concern was Guillain-Barre syndrome given the acute flaccid paralysis following COVID-19 infection. However, investigations revealed severe hypokalaemia (1.7 mmol/L) and primary hyperthyroidism. He was treated for thyrotoxic periodic paralysis (TPP) with β-blockers, antithyroid medications, and intravenous potassium chloride (KCl). Despite frequent monitoring of potassium, rebound hyperkalaemia occurred with prompt resolution of paralysis.
format Article
id doaj-art-e714b1d439684167b89ce8228c1618ad
institution Kabale University
issn 1687-9635
language English
publishDate 2022-01-01
publisher Wiley
record_format Article
series Case Reports in Medicine
spelling doaj-art-e714b1d439684167b89ce8228c1618ad2025-02-03T07:25:26ZengWileyCase Reports in Medicine1687-96352022-01-01202210.1155/2022/5827664Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the ThyroidSarah Ying Tse Tan0Jiaqing Xiong1Troy H Puar2Joan Khoo3Andy Jun-wei Wong4Shui Boon Soh5Department of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyDepartment of EndocrinologyA previously well 32-year-old Chinese male presented with acute bilateral upper and lower limb paralysis upon waking, ten days after the onset of COVID-19 infection. Examination revealed areflexia over all four limbs, associated with reduced muscle strength, but no sensory or cranial nerve deficit. Initial concern was Guillain-Barre syndrome given the acute flaccid paralysis following COVID-19 infection. However, investigations revealed severe hypokalaemia (1.7 mmol/L) and primary hyperthyroidism. He was treated for thyrotoxic periodic paralysis (TPP) with β-blockers, antithyroid medications, and intravenous potassium chloride (KCl). Despite frequent monitoring of potassium, rebound hyperkalaemia occurred with prompt resolution of paralysis.http://dx.doi.org/10.1155/2022/5827664
spellingShingle Sarah Ying Tse Tan
Jiaqing Xiong
Troy H Puar
Joan Khoo
Andy Jun-wei Wong
Shui Boon Soh
Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
Case Reports in Medicine
title Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
title_full Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
title_fullStr Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
title_full_unstemmed Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
title_short Acute Flaccid Tetraparesis after COVID-19 Infection: Think of the Thyroid
title_sort acute flaccid tetraparesis after covid 19 infection think of the thyroid
url http://dx.doi.org/10.1155/2022/5827664
work_keys_str_mv AT sarahyingtsetan acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid
AT jiaqingxiong acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid
AT troyhpuar acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid
AT joankhoo acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid
AT andyjunweiwong acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid
AT shuiboonsoh acuteflaccidtetraparesisaftercovid19infectionthinkofthethyroid