The critical role of Sirt1 in ischemic stroke
Ischemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. Howev...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1425560/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850036945305993216 |
|---|---|
| author | Ziyi Jia Ke Xu Ruobing Li Siyu Yang Long Chen Qianwen Zhang Shulin Li Xiaowei Sun |
| author_facet | Ziyi Jia Ke Xu Ruobing Li Siyu Yang Long Chen Qianwen Zhang Shulin Li Xiaowei Sun |
| author_sort | Ziyi Jia |
| collection | DOAJ |
| description | Ischemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. However, its mechanism of action during ischemic stroke remains ambiguous. The literature examination revealed the intricate involvement of Sirt1 in regulating both physiological and pathological mechanisms during ischemic stroke. Sirt1 demonstrates deacetylation effects on PGC-1α, HMGB1, FOXOs, and p53. It hinders the activation of NLRP3 inflammasome and NF-κB while also engaging with AMPK. It regulates inflammatory response, oxidative stress, mitochondrial dysfunction, autophagy, pro-death, and necrotic apoptosis. Therefore, the potential of Sirt1 as a therapeutic target for the management of ischemic stroke is promising. |
| format | Article |
| id | doaj-art-e70e8ea95ffd4f058bebab13ac08fdf8 |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e70e8ea95ffd4f058bebab13ac08fdf82025-08-20T02:57:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.14255601425560The critical role of Sirt1 in ischemic strokeZiyi Jia0Ke Xu1Ruobing Li2Siyu Yang3Long Chen4Qianwen Zhang5Shulin Li6Xiaowei Sun7The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe Second Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe Fourth Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaThe First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaIschemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. However, its mechanism of action during ischemic stroke remains ambiguous. The literature examination revealed the intricate involvement of Sirt1 in regulating both physiological and pathological mechanisms during ischemic stroke. Sirt1 demonstrates deacetylation effects on PGC-1α, HMGB1, FOXOs, and p53. It hinders the activation of NLRP3 inflammasome and NF-κB while also engaging with AMPK. It regulates inflammatory response, oxidative stress, mitochondrial dysfunction, autophagy, pro-death, and necrotic apoptosis. Therefore, the potential of Sirt1 as a therapeutic target for the management of ischemic stroke is promising.https://www.frontiersin.org/articles/10.3389/fphar.2025.1425560/fullischemic strokeSIRT1inflammationoxidative stressautophagymitochondrial dysfunction |
| spellingShingle | Ziyi Jia Ke Xu Ruobing Li Siyu Yang Long Chen Qianwen Zhang Shulin Li Xiaowei Sun The critical role of Sirt1 in ischemic stroke Frontiers in Pharmacology ischemic stroke SIRT1 inflammation oxidative stress autophagy mitochondrial dysfunction |
| title | The critical role of Sirt1 in ischemic stroke |
| title_full | The critical role of Sirt1 in ischemic stroke |
| title_fullStr | The critical role of Sirt1 in ischemic stroke |
| title_full_unstemmed | The critical role of Sirt1 in ischemic stroke |
| title_short | The critical role of Sirt1 in ischemic stroke |
| title_sort | critical role of sirt1 in ischemic stroke |
| topic | ischemic stroke SIRT1 inflammation oxidative stress autophagy mitochondrial dysfunction |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1425560/full |
| work_keys_str_mv | AT ziyijia thecriticalroleofsirt1inischemicstroke AT kexu thecriticalroleofsirt1inischemicstroke AT ruobingli thecriticalroleofsirt1inischemicstroke AT siyuyang thecriticalroleofsirt1inischemicstroke AT longchen thecriticalroleofsirt1inischemicstroke AT qianwenzhang thecriticalroleofsirt1inischemicstroke AT shulinli thecriticalroleofsirt1inischemicstroke AT xiaoweisun thecriticalroleofsirt1inischemicstroke AT ziyijia criticalroleofsirt1inischemicstroke AT kexu criticalroleofsirt1inischemicstroke AT ruobingli criticalroleofsirt1inischemicstroke AT siyuyang criticalroleofsirt1inischemicstroke AT longchen criticalroleofsirt1inischemicstroke AT qianwenzhang criticalroleofsirt1inischemicstroke AT shulinli criticalroleofsirt1inischemicstroke AT xiaoweisun criticalroleofsirt1inischemicstroke |