Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014
Background: A relatively well-established link was observed between metal mixtures exposure and neurodegenerative diseases. However, the relationship between metal mixtures exposure and serum neurofilament light chain (sNfL) concentrations, a valuable non-invasive biomarker of neurodegenerative dise...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015495 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591066221510656 |
|---|---|
| author | Yan Wang Keyi Zhang Hao Li Si Liu Linyao Ying Lu Xiang Na Liang Liangkai Chen Lin Xiao Gang Luo |
| author_facet | Yan Wang Keyi Zhang Hao Li Si Liu Linyao Ying Lu Xiang Na Liang Liangkai Chen Lin Xiao Gang Luo |
| author_sort | Yan Wang |
| collection | DOAJ |
| description | Background: A relatively well-established link was observed between metal mixtures exposure and neurodegenerative diseases. However, the relationship between metal mixtures exposure and serum neurofilament light chain (sNfL) concentrations, a valuable non-invasive biomarker of neurodegenerative diseases, in general adult populations remains understudied and unclear. Objective: This study seeks to elucidate the potential impact of metal mixtures exposure on sNfL concentrations in a representative sample of U.S. general adults. Methods: Twelve urinary metal levels, including barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), strontium (Sr), thallium (Tl), tungsten (W) and uranium (U), were analyzed in U.S. general adults recruited from the 2013–2014 National Health and Nutrition Examination Survey using inductively coupled plasma mass spectrometry (ICP-MS) after a simple dilution step. Urine samples are diluted with 2 % concentrated nitric acid (1:9). We employed a two-pronged approach, combining weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models, to examine the association between the multiple-metals effect and sNfL concentrations. Survey-weighted multivariate linear regression was used to explore the correlation between single-metal effect and sNfL concentrations. Results: With the increasing quartiles of log-transformed sNfL (log-sNfL) concentrations, the fourth quartile had a higher proportion of smokers and hypertensive individuals (P < 0.001). Cd (69.6 %) and Pb (8.9 %) were the primary drivers of the association between metal mixtures exposure and sNfL concentrations. Analysis of WQS and BKMR models showed a positive association between metal mixtures exposure and sNfL concentrations, especially in older, and male participants. Conclusion: In the U.S. general adult, a significant correlation between metal mixtures exposure and increased sNfL concentrations was observed, and urinary Cd levels play a pivotal role in this positive correlation. Notably, stronger risk associations were observed among elderly, males, smokers, and hypertensive individuals. The results could be significant for detecting and tracking the beginning of neurodegenerative diseases early, as well as helping to pinpoint individuals at high risk. |
| format | Article |
| id | doaj-art-e7074958b2e749998f08b79a92c59917 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-e7074958b2e749998f08b79a92c599172025-01-23T05:25:41ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117473Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014Yan Wang0Keyi Zhang1Hao Li2Si Liu3Linyao Ying4Lu Xiang5Na Liang6Liangkai Chen7Lin Xiao8Gang Luo9Xiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaXiangya School of Public Health, Central South University, Changsha 410078, China; Corresponding authors.Xiangya School of Public Health, Central South University, Changsha 410078, China; Corresponding authors.Background: A relatively well-established link was observed between metal mixtures exposure and neurodegenerative diseases. However, the relationship between metal mixtures exposure and serum neurofilament light chain (sNfL) concentrations, a valuable non-invasive biomarker of neurodegenerative diseases, in general adult populations remains understudied and unclear. Objective: This study seeks to elucidate the potential impact of metal mixtures exposure on sNfL concentrations in a representative sample of U.S. general adults. Methods: Twelve urinary metal levels, including barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), molybdenum (Mo), lead (Pb), antimony (Sb), tin (Sn), strontium (Sr), thallium (Tl), tungsten (W) and uranium (U), were analyzed in U.S. general adults recruited from the 2013–2014 National Health and Nutrition Examination Survey using inductively coupled plasma mass spectrometry (ICP-MS) after a simple dilution step. Urine samples are diluted with 2 % concentrated nitric acid (1:9). We employed a two-pronged approach, combining weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models, to examine the association between the multiple-metals effect and sNfL concentrations. Survey-weighted multivariate linear regression was used to explore the correlation between single-metal effect and sNfL concentrations. Results: With the increasing quartiles of log-transformed sNfL (log-sNfL) concentrations, the fourth quartile had a higher proportion of smokers and hypertensive individuals (P < 0.001). Cd (69.6 %) and Pb (8.9 %) were the primary drivers of the association between metal mixtures exposure and sNfL concentrations. Analysis of WQS and BKMR models showed a positive association between metal mixtures exposure and sNfL concentrations, especially in older, and male participants. Conclusion: In the U.S. general adult, a significant correlation between metal mixtures exposure and increased sNfL concentrations was observed, and urinary Cd levels play a pivotal role in this positive correlation. Notably, stronger risk associations were observed among elderly, males, smokers, and hypertensive individuals. The results could be significant for detecting and tracking the beginning of neurodegenerative diseases early, as well as helping to pinpoint individuals at high risk.http://www.sciencedirect.com/science/article/pii/S0147651324015495Serum neurofilament light chain concentrationsMetal mixtures exposureMultiple-metals effectNeurodegenerative diseasesNHANES |
| spellingShingle | Yan Wang Keyi Zhang Hao Li Si Liu Linyao Ying Lu Xiang Na Liang Liangkai Chen Lin Xiao Gang Luo Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 Ecotoxicology and Environmental Safety Serum neurofilament light chain concentrations Metal mixtures exposure Multiple-metals effect Neurodegenerative diseases NHANES |
| title | Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 |
| title_full | Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 |
| title_fullStr | Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 |
| title_full_unstemmed | Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 |
| title_short | Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 |
| title_sort | metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in u s general adults nhanes 2013 2014 |
| topic | Serum neurofilament light chain concentrations Metal mixtures exposure Multiple-metals effect Neurodegenerative diseases NHANES |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015495 |
| work_keys_str_mv | AT yanwang metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT keyizhang metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT haoli metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT siliu metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT linyaoying metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT luxiang metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT naliang metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT liangkaichen metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT linxiao metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 AT gangluo metalmixturesexposurewithriskofelevatedserumneurofilamentlightchainconcentrationsinusgeneraladultsnhanes20132014 |