Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment
Abstract Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival ra...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-024-02426-0 |
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| _version_ | 1832594518450372608 |
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| author | Yanyan Zhang Zhichao Yang Yuchen Liu Jinjin Pei Ruojie Li Yanhui Yang |
| author_facet | Yanyan Zhang Zhichao Yang Yuchen Liu Jinjin Pei Ruojie Li Yanhui Yang |
| author_sort | Yanyan Zhang |
| collection | DOAJ |
| description | Abstract Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function. Standard treatments for PC such as surgical resection, chemotherapy, and radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence and drug resistance. Given these limitations, new therapeutic approaches are being developed to target tumor metabolism. Dysregulation of cholesterol biosynthesis and alterations in fatty acids (FAs), such as palmitate, stearate, omega-3, and omega-6, have been observed in pancreatic cancer. These lipids serve as energy sources, signaling molecules, and essential components of cell membranes. Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. Abnormal lipid metabolism also contributes to drug resistance in PC. Despite these challenges, targeting lipid metabolism may offer a promising therapeutic strategy. By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression. |
| format | Article |
| id | doaj-art-e6f923e762274579aea4f79b6f30335e |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-e6f923e762274579aea4f79b6f30335e2025-01-19T12:37:30ZengBMCLipids in Health and Disease1476-511X2025-01-0124111510.1186/s12944-024-02426-0Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatmentYanyan Zhang0Zhichao Yang1Yuchen Liu2Jinjin Pei3Ruojie Li4Yanhui Yang5Qinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of TechnologyDepartment of Epidemiology and Health Statistics, School of Public Health, Dalian Medical UniversityQinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of TechnologyQinba State Key Laboratory of Biological Resources and Ecological Environment, Shaanxi Province Key Laboratory of Bio-Resources, College of Bioscience and Bioengineering, Bashan Mountains Bioresources Comprehensive Development C.I.C, Shaanxi University of TechnologyInterventional Therapy Department, The Second Affiliated Hospital of Dalian Medical University Emergency surgery Dapartment (Trauma center), The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyAbstract Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function. Standard treatments for PC such as surgical resection, chemotherapy, and radiotherapy. However, these therapies often face significant challenges, including biochemical recurrence and drug resistance. Given these limitations, new therapeutic approaches are being developed to target tumor metabolism. Dysregulation of cholesterol biosynthesis and alterations in fatty acids (FAs), such as palmitate, stearate, omega-3, and omega-6, have been observed in pancreatic cancer. These lipids serve as energy sources, signaling molecules, and essential components of cell membranes. Their accumulation fosters an immunosuppressive tumor microenvironment that supports cancer cell proliferation and metastasis. Moreover, lipid metabolism dysregulation within immune cells, particularly T cells, impairs immune surveillance and weakens the body’s defenses against cancer. Abnormal lipid metabolism also contributes to drug resistance in PC. Despite these challenges, targeting lipid metabolism may offer a promising therapeutic strategy. By enhancing lipid peroxidation, the induction of ferroptosis—a form of regulated cell death—could impair the survival of PC cells and hinder disease progression.https://doi.org/10.1186/s12944-024-02426-0Lipid metabolismTumor microenvironmentDrug resistanceFerroptosisCancer therapy |
| spellingShingle | Yanyan Zhang Zhichao Yang Yuchen Liu Jinjin Pei Ruojie Li Yanhui Yang Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment Lipids in Health and Disease Lipid metabolism Tumor microenvironment Drug resistance Ferroptosis Cancer therapy |
| title | Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment |
| title_full | Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment |
| title_fullStr | Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment |
| title_full_unstemmed | Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment |
| title_short | Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment |
| title_sort | targeting lipid metabolism novel insights and therapeutic advances in pancreatic cancer treatment |
| topic | Lipid metabolism Tumor microenvironment Drug resistance Ferroptosis Cancer therapy |
| url | https://doi.org/10.1186/s12944-024-02426-0 |
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