Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy
Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnif...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/368160 |
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| author | Kazuyoshi Yagi Atsuo Nakamura Atsuo Sekine David Graham |
| author_facet | Kazuyoshi Yagi Atsuo Nakamura Atsuo Sekine David Graham |
| author_sort | Kazuyoshi Yagi |
| collection | DOAJ |
| description | Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune gastritis. The mucosal pattern in autoimmune gastritis is that of closely arranged small round and oval pits, thus differing from the pattern seen in atrophic mucosa due to H. pylori infection. We speculate that this reflects differences in inflammation between the two types of gastritis. In autoimmune gastritis the inflammation is directed primarily against gastric glands, whereas in H. pylori infection the inflammation is directed against the bacteria on or near the surface and the damage initially affects the surface epithelium. During repair, the normal regular round pits are destroyed, whereas they remain largely intact in mucosa with autoimmune-associated atrophy. Confirmation of the features of autoimmune gastritis revealed by magnifying endoscopy would not only make the endoscopic diagnosis of autoimmune gastritis more accurate, but also help to elucidate changes in the surface epithelial structure of gastritis due to various causes. |
| format | Article |
| id | doaj-art-e6f8654e4e824c87a02942bf3ebc441b |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-e6f8654e4e824c87a02942bf3ebc441b2025-02-03T01:30:57ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/368160368160Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying EndoscopyKazuyoshi Yagi0Atsuo Nakamura1Atsuo Sekine2David Graham3Department of Internal Medicine, Niigata Prefectural Yoshida Hospital, Tsubame, Niigata 959-0242, JapanDepartment of Internal Medicine, Niigata Prefectural Yoshida Hospital, Tsubame, Niigata 959-0242, JapanDepartment of Internal Medicine, Niigata Prefectural Yoshida Hospital, Tsubame, Niigata 959-0242, JapanDepartment of Medicine, Michael DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USAAtrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune gastritis. The mucosal pattern in autoimmune gastritis is that of closely arranged small round and oval pits, thus differing from the pattern seen in atrophic mucosa due to H. pylori infection. We speculate that this reflects differences in inflammation between the two types of gastritis. In autoimmune gastritis the inflammation is directed primarily against gastric glands, whereas in H. pylori infection the inflammation is directed against the bacteria on or near the surface and the damage initially affects the surface epithelium. During repair, the normal regular round pits are destroyed, whereas they remain largely intact in mucosa with autoimmune-associated atrophy. Confirmation of the features of autoimmune gastritis revealed by magnifying endoscopy would not only make the endoscopic diagnosis of autoimmune gastritis more accurate, but also help to elucidate changes in the surface epithelial structure of gastritis due to various causes.http://dx.doi.org/10.1155/2012/368160 |
| spellingShingle | Kazuyoshi Yagi Atsuo Nakamura Atsuo Sekine David Graham Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy Case Reports in Medicine |
| title | Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy |
| title_full | Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy |
| title_fullStr | Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy |
| title_full_unstemmed | Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy |
| title_short | Features of the Atrophic Corpus Mucosa in Three Cases of Autoimmune Gastritis Revealed by Magnifying Endoscopy |
| title_sort | features of the atrophic corpus mucosa in three cases of autoimmune gastritis revealed by magnifying endoscopy |
| url | http://dx.doi.org/10.1155/2012/368160 |
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