EVALUATION OF CASES PRESENTING WITH MYELITIS IN CHILDHOOD
Objective: Myelitis is a monophasic inflammatory demyelinating disease of the spinal cord and brain, often of unknown origin. It is characterized with motor, sensory, and autonomic symptoms. In the childhood age group, it is most frequently seen as acute disseminated encephalomyelitis (ADEM) and tra...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Istanbul University Press
2021-04-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/6BB0C9D6CED0463D96FBB882A254079F |
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| Summary: | Objective: Myelitis is a monophasic inflammatory demyelinating disease of the spinal cord and brain, often of unknown origin. It is characterized with motor, sensory, and autonomic symptoms. In the childhood age group, it is most frequently seen as acute disseminated encephalomyelitis (ADEM) and transverse myelitis. In this study, the patients who presented to our clinic with myelitis were evaluated. Methods: Patients who were referred to Inonu University Paediatric Neurology Clinic with myelitis between 2012 and 2019 were included in the present study. Our patients’ diagnoses, demographic findings, treatments, and treatment responses were evaluated. Results: Thirty-eight patients, 23 with ADEM and 15 with transverse myelitis, were included in the study. The average age of patients was 8.52±4.19. Seventy-three-point nine percent (73.9%) of the ADEM patients were male, while 46.7% of the transverse myelitis patients were male. The average follow-up time with patients was 22.65±17.71 months. In terms of therapy, 28 of patients were given steroid, three were given IVIG, six were given steroid+IVIG, and one was given steroid+IVIG+plasmapheresis. Two of patients followed with transverse myelitis were polyphasic, while one was monophasic. Encephalopathy was seen in 82.6% of patients followed with ADEM, while seizure was seen in eight and fever was seen in 19. We had three anti-myelin oligodendrocyteglycoprotein (Anti-MOG) positive patients. One of these patients had optic neuritis attack after transverse myelitis and was diagnosed with neuromyelitis optic spectrum disorder. Conclusion: Myelitis is a significant neurological emergency rarely seen in childhood. The patients should be recognized and treated fast in terms of prognosis. In Anti-MOG positive patients, more care should be taken in treatment and the patients should be followed for a long period of time. |
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| ISSN: | 1305-6441 |