Knocking down hypoxia-induced Semaphorin 6B may attenuate the progression of cervical cancer through regulating macrophage M2 polarization

Knocking down hypoxia-induced Semaphorin 6B may attenuate the progression of cervical cancer through regulating macrophage M2 polarization

Abstract Background Cervical cancer is one of the most common malignancies in women, and its progression is closely associated with hypoxia and tumor-associated macrophages (TAMs) polarization in the tumor microenvironment (TME). The dynamic interaction between cancer cells and TAMs in the hypoxic t...

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Bibliographic Details
Main Authors: Shuyan Yi, Sha Hu, Wenhan Li, Jing Cai, Liqiong Cai, Lufang Wang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Hypoxia
Semaphorin 6B
Cervical cancer
Macrophage polarization
Online Access:https://doi.org/10.1186/s12967-025-06692-z
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