Quantification of Fas protein in CSF of patients with neurocysticercosis
Neurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic factor and the different evolutive forms of neurocysticercosis accompanied or not...
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Thieme Revinter Publicações
2012-04-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400007&lng=en&tlng=en |
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| author | José Augusto Camargo Paulo Henrique Ferreira Bertolucci |
| author_facet | José Augusto Camargo Paulo Henrique Ferreira Bertolucci |
| author_sort | José Augusto Camargo |
| collection | DOAJ |
| description | Neurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic factor and the different evolutive forms of neurocysticercosis accompanied or not by epileptic seizures. METHODS: Cerebrospinal fluid samples from 36 patients with a diagnosis of neurocysticercosis divided into the following groups: active cystic form (n=15), 9 patients with and 6 without seizures, and calcified form (=21), 9 with and 12 without seizures. Fourteen patients comprised the control group. Fas protein concentrations were determined by ELISA. RESULTS: Only the group of patients with calcified cysts without seizures presented cerebrospinal fluid levels of Fas similar to those of the control group. Higher levels were observed for the other groups. CONCLUSIONS: The present finding suggests high cerebrospinal fluid levels of soluble Fas protein, except for patients with calcified cysts without seizures. Significant differences were observed for the group with calcified cysts and seizures, suggesting greater neuronal damage in these patients. Replacement of the term inactive cyst with reactive inactive cyst is suggested. |
| format | Article |
| id | doaj-art-e6e8596d3cb94fc283041ca02e4e70e6 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2012-04-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-e6e8596d3cb94fc283041ca02e4e70e62025-08-20T02:04:10ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272012-04-0170426226610.1590/S0004-282X2012000400007S0004-282X2012000400007Quantification of Fas protein in CSF of patients with neurocysticercosisJosé Augusto Camargo0Paulo Henrique Ferreira Bertolucci1Universidade Federal de São PauloUniversidade Federal de São PauloNeurocysticercosis is a parasitic disease that affects the central nervous system. The objective of this study was to investigate the correlation between neuronal death evaluated by the quantification of Fas apoptotic factor and the different evolutive forms of neurocysticercosis accompanied or not by epileptic seizures. METHODS: Cerebrospinal fluid samples from 36 patients with a diagnosis of neurocysticercosis divided into the following groups: active cystic form (n=15), 9 patients with and 6 without seizures, and calcified form (=21), 9 with and 12 without seizures. Fourteen patients comprised the control group. Fas protein concentrations were determined by ELISA. RESULTS: Only the group of patients with calcified cysts without seizures presented cerebrospinal fluid levels of Fas similar to those of the control group. Higher levels were observed for the other groups. CONCLUSIONS: The present finding suggests high cerebrospinal fluid levels of soluble Fas protein, except for patients with calcified cysts without seizures. Significant differences were observed for the group with calcified cysts and seizures, suggesting greater neuronal damage in these patients. Replacement of the term inactive cyst with reactive inactive cyst is suggested.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400007&lng=en&tlng=enneurocisticercoseproteína ligante Faslíquido cefalorraquidianodano neuronal |
| spellingShingle | José Augusto Camargo Paulo Henrique Ferreira Bertolucci Quantification of Fas protein in CSF of patients with neurocysticercosis Arquivos de Neuro-Psiquiatria neurocisticercose proteína ligante Fas líquido cefalorraquidiano dano neuronal |
| title | Quantification of Fas protein in CSF of patients with neurocysticercosis |
| title_full | Quantification of Fas protein in CSF of patients with neurocysticercosis |
| title_fullStr | Quantification of Fas protein in CSF of patients with neurocysticercosis |
| title_full_unstemmed | Quantification of Fas protein in CSF of patients with neurocysticercosis |
| title_short | Quantification of Fas protein in CSF of patients with neurocysticercosis |
| title_sort | quantification of fas protein in csf of patients with neurocysticercosis |
| topic | neurocisticercose proteína ligante Fas líquido cefalorraquidiano dano neuronal |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012000400007&lng=en&tlng=en |
| work_keys_str_mv | AT joseaugustocamargo quantificationoffasproteinincsfofpatientswithneurocysticercosis AT paulohenriqueferreirabertolucci quantificationoffasproteinincsfofpatientswithneurocysticercosis |