Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development.

Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development.

Studies with genetically modified mice have implicated the transcriptional regulator STAT3 as a key modulator of bone development. STAT3-OKO knockout mouse lines were generated in two genetic backgrounds, pure C57BL/6 (STAT3-OKO-BL) and mixed C57BL/6, CD1 (STAT3-OKO-M). Both lines exhibited defectiv...

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Bibliographic Details
Main Authors: Rebecca K Davidson, Kylie Corry, Amos Orlofsky, Ping Li, Caleb E Russell, Amy Zhang, Mariana Moraes de Lima Perini, Carlie N Priddy, Andrew V Nguyen, Jiliang Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0315078
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