Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats
Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and q...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2018-0015 |
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| author | Somparn Nuntiya Saenthaweeuk Suphaket Naowaboot Jarinyaporn Thaeomor Atcharaporn Kukongviriyapan Veerapol |
| author_facet | Somparn Nuntiya Saenthaweeuk Suphaket Naowaboot Jarinyaporn Thaeomor Atcharaporn Kukongviriyapan Veerapol |
| author_sort | Somparn Nuntiya |
| collection | DOAJ |
| description | Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (p < 0.05) and was associated with decreased serum lipid peroxidation. |
| format | Article |
| id | doaj-art-e6dbd73734ac49caa168abaca052ea35 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e6dbd73734ac49caa168abaca052ea352025-02-02T12:01:38ZengSciendoActa Pharmaceutica1846-95582018-06-0168218519710.2478/acph-2018-0015acph-2018-0015Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in ratsSomparn Nuntiya0Saenthaweeuk Suphaket1Naowaboot Jarinyaporn2Thaeomor Atcharaporn3Kukongviriyapan Veerapol4Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus PathumThani, Thailand 12120Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus PathumThani, Thailand 12120Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus PathumThani, Thailand 12120School of Preclinical Science, Institute of Science, Suranaree University of TechnologyNakhon Ratchasima, Thailand 30000Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand 40002Cymbopogon citratus (DC) Stapf., commonly known as lemongrass, possesses strong antioxidant and cardiotonic properties. Lemongrass water extract contains several polyphenolic compounds including gallic acid, isoquercetin, quercetin, rutin, catechin and tannic acid. Rutin, isoquercetin catechin and quercetin are the flavonoids most abundantly found in the extract. The extract significantly decreased total cholesterol, low-density lipoprotein and atherogenic index in rats after treatment (p < 0.05). Expression of genes and protein of sterol regulatory element binding protein-1c (SREBP1c) and HMG-CoA reductase (HMGR) was also lowered significantly in treated groups (p < 0.05). Moreover, serum antioxidant capacity increased in treated rats in comparison with untreated ones (p < 0.05) and was associated with decreased serum lipid peroxidation.https://doi.org/10.2478/acph-2018-0015cymbopogon citratuslipid profileantioxidantsrebp1chmg-coa reductase |
| spellingShingle | Somparn Nuntiya Saenthaweeuk Suphaket Naowaboot Jarinyaporn Thaeomor Atcharaporn Kukongviriyapan Veerapol Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats Acta Pharmaceutica cymbopogon citratus lipid profile antioxidant srebp1c hmg-coa reductase |
| title | Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| title_full | Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| title_fullStr | Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| title_full_unstemmed | Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| title_short | Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| title_sort | effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats |
| topic | cymbopogon citratus lipid profile antioxidant srebp1c hmg-coa reductase |
| url | https://doi.org/10.2478/acph-2018-0015 |
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