Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non-inferiority trials (the CLIP-II and CLIPNZ-II trials)

Cryopreserved platelets compared with liquid-stored platelets for the treatment of surgical bleeding: protocol for two multicentre randomised controlled blinded non-inferiority trials (the CLIP-II and CLIPNZ-II trials)

Introduction Cryopreservation at −80°C in dimethylsulphoxide extends platelet shelf-life from 7 days to 2 years. Only limited comparative trial data supports the safety and effectiveness of cryopreserved platelets as a treatment for surgical bleeding. Cryopreserved platelets are not currently regist...

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Main Authors: Rachael Parke, Chris Walker, Laurence Weinberg, James Moore, Raymond Hu, Kelly Byrne, Shay McGuinness, Alisa Higgins, Julian Smith, Anthony Holley, Sarah Morley, Denese C Marks, Eileen Gilder, Alistair Royse, David Gattas, Craig French, Glenn Eastwood, Zoe McQuilten, Erica Wood, Michael C. Reade, Belinda Howe, Leanlove Navarra, Richard Charlewood, Lacey Johnson, Denese C. Marks, David Irving, Paul Bannon, Sean Galvin, Katia Hayes
Format: Article
Language:English
Published: BMJ Publishing Group 2022-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/12/12/e068933.full
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