The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia
Background. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods. Seventy-five sc...
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Wiley
2016-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/9178523 |
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| author | Yukako Obata Yushi U. Adachi Katsumi Suzuki Taiga Itagaki Hiromi Kato Maiko Satomoto Yoshiki Nakajima |
| author_facet | Yukako Obata Yushi U. Adachi Katsumi Suzuki Taiga Itagaki Hiromi Kato Maiko Satomoto Yoshiki Nakajima |
| author_sort | Yukako Obata |
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| description | Background. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods. Seventy-five scheduled surgical patients were randomly allocated into three groups. The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg−1 h−1. Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol. Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn. Results. The hypnotic doses of M2 were significantly larger (D1: 91.4±30.9, M1: 90.7±26.7, and M2: 118.4±40.2 mg, resp. (mean ± SD). p<0.005). Age and gender were selected as statistically significant covariates using general linear model-ANOVA. The blood concentration showed no significant difference among the groups (3.73±2.34, 4.10±3.04, and 4.70±2.12 μg mL−1, resp.). Conclusion. The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925. |
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| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2016-01-01 |
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| series | Anesthesiology Research and Practice |
| spelling | doaj-art-e6c11997694c4bd7afe7ab436af140152025-02-03T01:20:14ZengWileyAnesthesiology Research and Practice1687-69621687-69702016-01-01201610.1155/2016/91785239178523The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of AnesthesiaYukako Obata0Yushi U. Adachi1Katsumi Suzuki2Taiga Itagaki3Hiromi Kato4Maiko Satomoto5Yoshiki Nakajima6Department of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, JapanDepartment of Intensive Care Medicine, Tokyo Medical and Dental University Medical Hospital, Tokyo, JapanDepartment of Anesthesia, Enshu Hospital, Hamamatsu, JapanPulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, USADepartment of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, JapanDepartment of Anesthesiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, JapanDepartment of Intensive Care Unit, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 4313192, JapanBackground. Propofol is a popular intravenous anesthetic and varieties of formulations were produced from different laboratories. The present study compared efficacy of propofol of different laboratories and different concentrations (1 and 2%) during induction of anesthesia. Methods. Seventy-five scheduled surgical patients were randomly allocated into three groups. The patients of group D1 received AstraZeneca Diprivan 1% (Osaka, Japan) at a rate of 40 mg kg−1 h−1. Group M1 was given 1% Maruishi (Maruishi Pharmaceutical, Osaka, Japan) and group M2 was given 2% formulation at the same rate of propofol. Achieving hypnosis was defined as failure to open their eyes in response to a verbal command and the venous blood sample was withdrawn. Results. The hypnotic doses of M2 were significantly larger (D1: 91.4±30.9, M1: 90.7±26.7, and M2: 118.4±40.2 mg, resp. (mean ± SD). p<0.005). Age and gender were selected as statistically significant covariates using general linear model-ANOVA. The blood concentration showed no significant difference among the groups (3.73±2.34, 4.10±3.04, and 4.70±2.12 μg mL−1, resp.). Conclusion. The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925.http://dx.doi.org/10.1155/2016/9178523 |
| spellingShingle | Yukako Obata Yushi U. Adachi Katsumi Suzuki Taiga Itagaki Hiromi Kato Maiko Satomoto Yoshiki Nakajima The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia Anesthesiology Research and Practice |
| title | The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia |
| title_full | The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia |
| title_fullStr | The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia |
| title_full_unstemmed | The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia |
| title_short | The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia |
| title_sort | influence of differences in solvents and concentration on the efficacy of propofol at induction of anesthesia |
| url | http://dx.doi.org/10.1155/2016/9178523 |
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