Development of nifedipine isosteres: an integrated approach to the design, synthesis, and biological assessment of calcium channel blockers
This study reports the synthesis of a series of calcium channel blockers via Biginelli’s reaction. The core dihydropyridine (DHP) scaffold, an isostere of nifedipine, was synthesized using three aldehydes incorporated with trifluoromethyl (–CF3) substitutions at the ortho, meta, and para positions....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2025.1581037/full |
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