Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.

Cytotoxic capacity of SIV-specific CD8(+) T cells against primary autologous targets correlates with immune control in SIV-infected rhesus macaques.

Although the study of non-human primates has resulted in important advances for understanding HIV-specific immunity, a clear correlate of immune control over simian immunodeficiency virus (SIV) replication has not been found to date. In this study, CD8(+) T-cell cytotoxic capacity was examined to de...

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Main Authors: Daniel Mendoza, Stephen A Migueles, Julia E Rood, Bennett Peterson, Sarah Johnson, Nicole Doria-Rose, Douglas Schneider, Eva Rakasz, Matthew T Trivett, Charles M Trubey, Vicky Coalter, Claire W Hallahan, David Watkins, Genoveffa Franchini, Jeffrey D Lifson, Mark Connors
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003195&type=printable
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