Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer?
A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on clinical characteristics may remain at unacceptably high risk of axillary disea...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/973245 |
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| _version_ | 1832560355739435008 |
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| author | Kenneth D. Westover M. Brandon Westover Eric P. Winer Andrea L. Richardson J. Dirk Iglehart Rinaa S. Punglia |
| author_facet | Kenneth D. Westover M. Brandon Westover Eric P. Winer Andrea L. Richardson J. Dirk Iglehart Rinaa S. Punglia |
| author_sort | Kenneth D. Westover |
| collection | DOAJ |
| description | A negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on clinical characteristics may remain at unacceptably high risk of axillary disease even after a negative SLN biopsy result. A Bayesian nomogram was designed to combine the probability of axillary disease prior to nodal biopsy with customized test characteristics for an SLN biopsy and provides the probability of axillary disease despite a negative SLN biopsy. Users may individualize the sensitivity of an SLN biopsy based on factors known to modify the sensitivity of the procedure. This tool may be useful in identifying patients who should have expanded upfront exploration of the axilla or comprehensive axillary irradiation. |
| format | Article |
| id | doaj-art-e6ab8f8baaa04c2a93ec9be638fc7f9b |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-e6ab8f8baaa04c2a93ec9be638fc7f9b2025-02-03T01:27:49ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/973245973245Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer?Kenneth D. Westover0M. Brandon Westover1Eric P. Winer2Andrea L. Richardson3J. Dirk Iglehart4Rinaa S. Punglia5Harvard Radiation Oncology Program, Boston, MA 02115, USADepartment of Neurology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Pathology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Surgery, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USADepartment of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USAA negative sentinel lymph node (SLN) biopsy spares many breast cancer patients the complications associated with lymph node irradiation or additional surgery. However, patients at high risk for nodal involvement based on clinical characteristics may remain at unacceptably high risk of axillary disease even after a negative SLN biopsy result. A Bayesian nomogram was designed to combine the probability of axillary disease prior to nodal biopsy with customized test characteristics for an SLN biopsy and provides the probability of axillary disease despite a negative SLN biopsy. Users may individualize the sensitivity of an SLN biopsy based on factors known to modify the sensitivity of the procedure. This tool may be useful in identifying patients who should have expanded upfront exploration of the axilla or comprehensive axillary irradiation.http://dx.doi.org/10.4061/2011/973245 |
| spellingShingle | Kenneth D. Westover M. Brandon Westover Eric P. Winer Andrea L. Richardson J. Dirk Iglehart Rinaa S. Punglia Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? International Journal of Breast Cancer |
| title | Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? |
| title_full | Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? |
| title_fullStr | Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? |
| title_full_unstemmed | Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? |
| title_short | Should a Sentinel Node Biopsy Be Performed in Patients with High-Risk Breast Cancer? |
| title_sort | should a sentinel node biopsy be performed in patients with high risk breast cancer |
| url | http://dx.doi.org/10.4061/2011/973245 |
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