The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices
Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/5438157 |
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| author | Cuiling Zhu Ran Cui Mingming Gao Sharvan Rampersad Hui You Chunjun Sheng Peng Yang Hui Sheng Xiaoyun Cheng Le Bu Shen Qu |
| author_facet | Cuiling Zhu Ran Cui Mingming Gao Sharvan Rampersad Hui You Chunjun Sheng Peng Yang Hui Sheng Xiaoyun Cheng Le Bu Shen Qu |
| author_sort | Cuiling Zhu |
| collection | DOAJ |
| description | Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. Results. AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable‐adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs = 3.00 and 95% CI [1.02–8.84]) and males (ORs = 6.07 and 95% CI [2.16–17.06]) in the highest quartile (Q4) of serum UA. Conclusions. Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship. |
| format | Article |
| id | doaj-art-e6a74d081d404498959282115db5c328 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e6a74d081d404498959282115db5c3282025-02-03T05:47:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/54381575438157The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic IndicesCuiling Zhu0Ran Cui1Mingming Gao2Sharvan Rampersad3Hui You4Chunjun Sheng5Peng Yang6Hui Sheng7Xiaoyun Cheng8Le Bu9Shen Qu10Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia College of Pharmacy, Athens, GA, USADepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, ChinaObjective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. Results. AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable‐adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs = 3.00 and 95% CI [1.02–8.84]) and males (ORs = 6.07 and 95% CI [2.16–17.06]) in the highest quartile (Q4) of serum UA. Conclusions. Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship.http://dx.doi.org/10.1155/2017/5438157 |
| spellingShingle | Cuiling Zhu Ran Cui Mingming Gao Sharvan Rampersad Hui You Chunjun Sheng Peng Yang Hui Sheng Xiaoyun Cheng Le Bu Shen Qu The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices International Journal of Endocrinology |
| title | The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices |
| title_full | The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices |
| title_fullStr | The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices |
| title_full_unstemmed | The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices |
| title_short | The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices |
| title_sort | associations of serum uric acid with obesity related acanthosis nigricans and related metabolic indices |
| url | http://dx.doi.org/10.1155/2017/5438157 |
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