Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study
Abstract The fibrosis‐4 index (FIB‐4) is a noninvasive fibrosis test that is recommended for patients who are at risk of developing hepatic fibrosis. The aim of the study was to explore the correlation between FIB‐4 index and the decline of cognitive function among older patients with hypertension....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14890 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850066742936600576 |
|---|---|
| author | Hong Ding Jingtao Wang Shu Liu Yafei Xie Xiaowei Zhang Jing Yu |
| author_facet | Hong Ding Jingtao Wang Shu Liu Yafei Xie Xiaowei Zhang Jing Yu |
| author_sort | Hong Ding |
| collection | DOAJ |
| description | Abstract The fibrosis‐4 index (FIB‐4) is a noninvasive fibrosis test that is recommended for patients who are at risk of developing hepatic fibrosis. The aim of the study was to explore the correlation between FIB‐4 index and the decline of cognitive function among older patients with hypertension. The study used a cross‐sectional design to analyze data obtained from the NHANES 2011–2014. The significance of the FIB‐4 index correlation with cognitive function in individuals over the age of 60 was evaluated via multivariate regression models. The nonlinear link was described and fitted smoothed curves. There were a total of 2039 participants in the study, and those with a higher FIB‐4 index were more susceptible to developing cognitive decline. In the completely adjusted model, the association remained statistically significant between the FIB‐4 index and poor cognitive function as measured by CERAD: Total Score (OR = 0.72, 0.57−0.91), Animal Fluency Score (OR = 0.66, 0.48−0.91), and Digit Symbol Score (OR = 0.36, 0.17−0.77). A nonlinear association was found between the FIB‐4 and poor cognitive ability: Total Score, CERAD: Score Delayed Recall, Digit Symbol Score, and Animal Fluency Score. In elderly patients with hypertension, a high FIB‐4 index is correlated with an increased prevalence of cognitive decline. Hence, the FIB‐4 index could potentially serve as a valuable tool for determining individuals with hypertension who are susceptible to both liver‐related complications and cognitive impairment. |
| format | Article |
| id | doaj-art-e6a53d7bcbe049b6ae2bb5167fb9759d |
| institution | DOAJ |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-e6a53d7bcbe049b6ae2bb5167fb9759d2025-08-20T02:48:39ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-11-0126111246125510.1111/jch.14890Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional studyHong Ding0Jingtao Wang1Shu Liu2Yafei Xie3Xiaowei Zhang4Jing Yu5Department of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaDepartment of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaDepartment of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaDepartment of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaDepartment of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaDepartment of Cardiovascular Medicine Lanzhou University Second Hospital Lanzhou ChinaAbstract The fibrosis‐4 index (FIB‐4) is a noninvasive fibrosis test that is recommended for patients who are at risk of developing hepatic fibrosis. The aim of the study was to explore the correlation between FIB‐4 index and the decline of cognitive function among older patients with hypertension. The study used a cross‐sectional design to analyze data obtained from the NHANES 2011–2014. The significance of the FIB‐4 index correlation with cognitive function in individuals over the age of 60 was evaluated via multivariate regression models. The nonlinear link was described and fitted smoothed curves. There were a total of 2039 participants in the study, and those with a higher FIB‐4 index were more susceptible to developing cognitive decline. In the completely adjusted model, the association remained statistically significant between the FIB‐4 index and poor cognitive function as measured by CERAD: Total Score (OR = 0.72, 0.57−0.91), Animal Fluency Score (OR = 0.66, 0.48−0.91), and Digit Symbol Score (OR = 0.36, 0.17−0.77). A nonlinear association was found between the FIB‐4 and poor cognitive ability: Total Score, CERAD: Score Delayed Recall, Digit Symbol Score, and Animal Fluency Score. In elderly patients with hypertension, a high FIB‐4 index is correlated with an increased prevalence of cognitive decline. Hence, the FIB‐4 index could potentially serve as a valuable tool for determining individuals with hypertension who are susceptible to both liver‐related complications and cognitive impairment.https://doi.org/10.1111/jch.14890cognitive functionFIB‐4 indexhypertension |
| spellingShingle | Hong Ding Jingtao Wang Shu Liu Yafei Xie Xiaowei Zhang Jing Yu Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study The Journal of Clinical Hypertension cognitive function FIB‐4 index hypertension |
| title | Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study |
| title_full | Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study |
| title_fullStr | Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study |
| title_full_unstemmed | Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study |
| title_short | Association between fibrosis‐4 index and cognitive impairment in elderly patients with hypertension: A cross‐sectional study |
| title_sort | association between fibrosis 4 index and cognitive impairment in elderly patients with hypertension a cross sectional study |
| topic | cognitive function FIB‐4 index hypertension |
| url | https://doi.org/10.1111/jch.14890 |
| work_keys_str_mv | AT hongding associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy AT jingtaowang associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy AT shuliu associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy AT yafeixie associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy AT xiaoweizhang associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy AT jingyu associationbetweenfibrosis4indexandcognitiveimpairmentinelderlypatientswithhypertensionacrosssectionalstudy |