Diagnosis and Treatment of Polycythemia Vera in Pakistan; Barriers and Possible Solutions
This review aims to highlight the challenges encountered in managing Polycythemia Vera in resource-limited settings and to suggest a cost-effective strategy for timely diagnosis and treatment. Presentation to healthcare facilities at an advanced stage due to lack of awareness and limited access to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Liaquat National Hospital and Medical College
2025-07-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/5bb8f639-936c-4ae3-acc0-71d0fafb4177.pdf |
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| Summary: | This review aims to highlight the challenges encountered in managing Polycythemia Vera in resource-limited settings and to suggest
a cost-effective strategy for timely diagnosis and treatment. Presentation to healthcare facilities at an advanced stage due to lack of
awareness and limited access to medical care, delay in the diagnosis due to inadequate healthcare infrastructure, unavailability of
molecular testing in the majority of centers, and suboptimal disease management, primarily due to lack of physician awareness and
expertise in handling this condition are the key factors contributing to the higher rates of complications, including thrombotic events
and disease progression, ultimately leading to poorer patient prognoses in Pakistani population. This review describes and evaluates
a cost-effective diagnostic and treatment approach to Polycythemia Vera to reduce the morbidity and mortality of the disorder in
Pakistan. A tailored investigation plan comprising of JAK2 mutation and serum erythropoietin levels and minimal cytoreductive
therapy combined with phlebotomy and anti-platelet agent can be implemented to achieve optimal management of the disease in a
resource-constrained country |
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| ISSN: | 2707-3521 2708-9134 |