Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison
IntroductionAs the lifespan of companion animals extends, the incidence of tumor also increases. Among these tumors, lymphoma is reported as the most prevalent hematopoietic tumor with a 80-90% prevalence rate. Ongoing research spans multiple domains, aiming to uncover novel therapeutic targets, inc...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1473421/full |
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| author | Yeji Kim Yeji Kim Jihyun Kim Jihyun Kim Yunji Song Yunji Song Keunhwan Jang Se Eun Kim Se Eun Kim Se Eun Kim Ha-Jung Kim Ha-Jung Kim |
| author_facet | Yeji Kim Yeji Kim Jihyun Kim Jihyun Kim Yunji Song Yunji Song Keunhwan Jang Se Eun Kim Se Eun Kim Se Eun Kim Ha-Jung Kim Ha-Jung Kim |
| author_sort | Yeji Kim |
| collection | DOAJ |
| description | IntroductionAs the lifespan of companion animals extends, the incidence of tumor also increases. Among these tumors, lymphoma is reported as the most prevalent hematopoietic tumor with a 80-90% prevalence rate. Ongoing research spans multiple domains, aiming to uncover novel therapeutic targets, including small molecular weight inhibitors, antibody treatments, and subtype-specific selective agents.MethodsTranscriptional profiling was performed on canine lymphoma samples to identify genes and functional pathways associated with pathogenesis, treatment response, and prognosis. Additionally, genes with potential relevance to the clinical characteristics of T-cell lymphoma (TCL), which is characterized by a low treatment response and poor prognosis, were identified through a comparative analysis of different lymphoma subtypes.ResultsWithin the canine lymphoma group, HERC5 showed consistent upregulation, a gene similarly implicated in human acute myeloid leukemia but previously no reports exist. Additionally, noteworthy genes, including IKZF2, CCL4, SAA1, and CD40, exhibited differential expression in the TCL group compared to the B-cell lymphoma (BCL) group.DiscussionThe upregulation of HERC5 may impact on canine lymphoma pathogenicity. Furthermore, the upregulation of IKZF2, CCL4, and SAA1, along with the downregulation of CD40, may contribute to adverse clinical characteristics of TCL in dogs. |
| format | Article |
| id | doaj-art-e6903de2b989490893c6cb55c0b04315 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-e6903de2b989490893c6cb55c0b043152025-01-22T14:11:32ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.14734211473421Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparisonYeji Kim0Yeji Kim1Jihyun Kim2Jihyun Kim3Yunji Song4Yunji Song5Keunhwan Jang6Se Eun Kim7Se Eun Kim8Se Eun Kim9Ha-Jung Kim10Ha-Jung Kim11Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBK21 FOUR Program, Chonnam National University, Gwangju, Republic of KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBK21 FOUR Program, Chonnam National University, Gwangju, Republic of KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBK21 FOUR Program, Chonnam National University, Gwangju, Republic of KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBK21 FOUR Program, Chonnam National University, Gwangju, Republic of KoreaDepartment of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBiomaterial R&BD Center, Chonnam National University, Gwangju, Republic of KoreaDepartment of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of KoreaBK21 FOUR Program, Chonnam National University, Gwangju, Republic of KoreaIntroductionAs the lifespan of companion animals extends, the incidence of tumor also increases. Among these tumors, lymphoma is reported as the most prevalent hematopoietic tumor with a 80-90% prevalence rate. Ongoing research spans multiple domains, aiming to uncover novel therapeutic targets, including small molecular weight inhibitors, antibody treatments, and subtype-specific selective agents.MethodsTranscriptional profiling was performed on canine lymphoma samples to identify genes and functional pathways associated with pathogenesis, treatment response, and prognosis. Additionally, genes with potential relevance to the clinical characteristics of T-cell lymphoma (TCL), which is characterized by a low treatment response and poor prognosis, were identified through a comparative analysis of different lymphoma subtypes.ResultsWithin the canine lymphoma group, HERC5 showed consistent upregulation, a gene similarly implicated in human acute myeloid leukemia but previously no reports exist. Additionally, noteworthy genes, including IKZF2, CCL4, SAA1, and CD40, exhibited differential expression in the TCL group compared to the B-cell lymphoma (BCL) group.DiscussionThe upregulation of HERC5 may impact on canine lymphoma pathogenicity. Furthermore, the upregulation of IKZF2, CCL4, and SAA1, along with the downregulation of CD40, may contribute to adverse clinical characteristics of TCL in dogs.https://www.frontiersin.org/articles/10.3389/fvets.2024.1473421/fulllymphomaT-cellB-celltranscriptomemicroarrayheterogeneity |
| spellingShingle | Yeji Kim Yeji Kim Jihyun Kim Jihyun Kim Yunji Song Yunji Song Keunhwan Jang Se Eun Kim Se Eun Kim Se Eun Kim Ha-Jung Kim Ha-Jung Kim Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison Frontiers in Veterinary Science lymphoma T-cell B-cell transcriptome microarray heterogeneity |
| title | Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison |
| title_full | Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison |
| title_fullStr | Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison |
| title_full_unstemmed | Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison |
| title_short | Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison |
| title_sort | sequential transcriptome profiling comparative analysis of normal and canine lymphoma preceding detailed t cell and b cell subtype comparison |
| topic | lymphoma T-cell B-cell transcriptome microarray heterogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1473421/full |
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