DNA-based hydrogels for bone regeneration: A promising tool for bone organoids
DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These hydrogels facilitate the formation of spatial bone structures through bulk hydrogel fabricating, microsphere formatting, and 3D printing. Furthermore, the bone microenvironment ca...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000602 |
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| author | Xiang Wu Yan Hu Shihao Sheng Huijian Yang Zuhao Li Qinglin Han Qin Zhang Jiacan Su |
| author_facet | Xiang Wu Yan Hu Shihao Sheng Huijian Yang Zuhao Li Qinglin Han Qin Zhang Jiacan Su |
| author_sort | Xiang Wu |
| collection | DOAJ |
| description | DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These hydrogels facilitate the formation of spatial bone structures through bulk hydrogel fabricating, microsphere formatting, and 3D printing. Furthermore, the bone microenvironment can be finely tuned by leveraging the degradation products, nanostructure, targeting, and delivery capabilities inherent to DNA-based materials. In this review, we underscore the advantages of DNA-based hydrogels, detailing their composition, gelation techniques, and structure optimization. We then delineate three critical elements in the promotion of bone regeneration using DNA-based hydrogels: (i) osteogenesis driven by phosphate ions, plasmids, and oligodeoxynucleotides (ODNs) that enhance mineralization and promote gene and protein expression; (ii) vascularization facilitated by tetrahedral DNA nanostructures (TDNs) and aptamers, which boosts gene expression and targeted release; (iii) immunomodulation achieved through loaded factors, TDNs, and bound ions that stimulate macrophage polarization and exhibit antibacterial properties. With these advantages and properties, these DNA-based hydrogels can be used to construct bone organoids, providing an innovative tool for disease modeling and therapeutic applications in bone tissue engineering. Finally, we discuss the current challenges and future prospects, emphasizing the potential impacts and applications in regenerative medicine. |
| format | Article |
| id | doaj-art-e688696b39e042b6a2546dc18990785f |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-e688696b39e042b6a2546dc18990785f2025-01-27T04:22:08ZengElsevierMaterials Today Bio2590-00642025-04-0131101502DNA-based hydrogels for bone regeneration: A promising tool for bone organoidsXiang Wu0Yan Hu1Shihao Sheng2Huijian Yang3Zuhao Li4Qinglin Han5Qin Zhang6Jiacan Su7Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; School of Medicine, Shanghai University, Shanghai, 200444, China; School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, ChinaDepartment of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, ChinaDepartment of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Department of Clinical Laboratory, Shanghai Zhongye Hospital, Shanghai, 201941, ChinaDepartment of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.Department of Orthopedics, The Affiliated Hospital of Nantong University, Nantong, 226001, China; Corresponding authors. Department of Orthopedics, The Affiliated Hospital of Nantong University, Nantong, 226001, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Sanming Institute of Translational Medicine, Sanming, 365004, China; Corresponding author. Organoid Research Center, Shanghai University, Shanghai, 200444, China.Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Organoid Research Center, Shanghai University, Shanghai, 200444, China; National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Corresponding author. National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai, 200444, China.DNA-based hydrogels stand out for bone regeneration due to their exceptional biocompatibility and programmability. These hydrogels facilitate the formation of spatial bone structures through bulk hydrogel fabricating, microsphere formatting, and 3D printing. Furthermore, the bone microenvironment can be finely tuned by leveraging the degradation products, nanostructure, targeting, and delivery capabilities inherent to DNA-based materials. In this review, we underscore the advantages of DNA-based hydrogels, detailing their composition, gelation techniques, and structure optimization. We then delineate three critical elements in the promotion of bone regeneration using DNA-based hydrogels: (i) osteogenesis driven by phosphate ions, plasmids, and oligodeoxynucleotides (ODNs) that enhance mineralization and promote gene and protein expression; (ii) vascularization facilitated by tetrahedral DNA nanostructures (TDNs) and aptamers, which boosts gene expression and targeted release; (iii) immunomodulation achieved through loaded factors, TDNs, and bound ions that stimulate macrophage polarization and exhibit antibacterial properties. With these advantages and properties, these DNA-based hydrogels can be used to construct bone organoids, providing an innovative tool for disease modeling and therapeutic applications in bone tissue engineering. Finally, we discuss the current challenges and future prospects, emphasizing the potential impacts and applications in regenerative medicine.http://www.sciencedirect.com/science/article/pii/S2590006425000602DNA-Based hydrogelsBone organoidsOsteogenesisVascularizationImmno-modulation |
| spellingShingle | Xiang Wu Yan Hu Shihao Sheng Huijian Yang Zuhao Li Qinglin Han Qin Zhang Jiacan Su DNA-based hydrogels for bone regeneration: A promising tool for bone organoids Materials Today Bio DNA-Based hydrogels Bone organoids Osteogenesis Vascularization Immno-modulation |
| title | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids |
| title_full | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids |
| title_fullStr | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids |
| title_full_unstemmed | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids |
| title_short | DNA-based hydrogels for bone regeneration: A promising tool for bone organoids |
| title_sort | dna based hydrogels for bone regeneration a promising tool for bone organoids |
| topic | DNA-Based hydrogels Bone organoids Osteogenesis Vascularization Immno-modulation |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000602 |
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