Birch pollen allergen-induced dsDNA release activates cGAS-STING signaling and type 2 immune response in mice

Birch pollen allergen-induced dsDNA release activates cGAS-STING signaling and type 2 immune response in mice

Summary: Detecting cytoplasmic or extracellular DNA from host or pathogen origin by DNA sensor cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) triggers immune responses with secretion of type I interferons and inflammatory cytokines. However, STING agonists function as type...

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Bibliographic Details
Main Authors: Pauline Chenuet, Manon Mellier, Yasmine Messaoud-Nacer, Elodie Culerier, Quentin Marquant, Louis Fauconnier, Nathalie Rouxel, Aurélie Ledru, Stéphanie Rose, Bernhard Ryffel, Lionel Apetoh, Valérie F.J. Quesniaux, Dieudonnée Togbe
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Immune response
Immunology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225005851
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