Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan
Abstract Purpose Polycystic ovary syndrome (PCOS) significantly affects women. This study investigated the association between serum anti‐Müllerian hormone (AMH) levels and menstrual cycle disorders, and AMH for PCOS in a general cohort of young Japanese women. Methods We measured serum AMH levels i...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12615 |
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| author | Natsuki Miyake Satoko Osuka Isao Ohsawa Takashi Tonoike Tomoko Uno Kazuo Tsuzuki Bayasula Reina Sonehara Ayako Muraoka Tomoko Nakamura Maki Goto Akira Iwase Hiroaki Kajiyama |
| author_facet | Natsuki Miyake Satoko Osuka Isao Ohsawa Takashi Tonoike Tomoko Uno Kazuo Tsuzuki Bayasula Reina Sonehara Ayako Muraoka Tomoko Nakamura Maki Goto Akira Iwase Hiroaki Kajiyama |
| author_sort | Natsuki Miyake |
| collection | DOAJ |
| description | Abstract Purpose Polycystic ovary syndrome (PCOS) significantly affects women. This study investigated the association between serum anti‐Müllerian hormone (AMH) levels and menstrual cycle disorders, and AMH for PCOS in a general cohort of young Japanese women. Methods We measured serum AMH levels in 528 healthy female students at two universities in Japan between 2014 and 2020. We investigated the association between serum AMH levels and hormone levels, menstrual cycle, and body mass index. Results The mean (±standard deviation) AMH level was 4.78 ± 2.88 ng/mL. Correlations were observed between serum AMH and luteinizing hormone (LH) or LH/follicle‐stimulating hormone (FSH) levels in women with irregular menstruation (LH: r = 0.542, p < 0.001; LH/FSH: r = 0.584, p < 0.001). The optimal serum AMH cutoff value that predicted LH ≥7.1 IU/L and LH/FSH ≥1.21 (PCOS diagnostic criteria revised by Japan Society of Obstetrics and Gynecology) in women with menstrual irregularities was 5.30 ng/mL (area under the curve: 0.815, sensitivity: 84.2%, specificity: 70.3%). Conclusions Serum AMH can be measured during annual health checkups and may be a useful biomarker for early and arcuate diagnosis and intervention in women with PCOS. |
| format | Article |
| id | doaj-art-e6841d4a93ca4b6bb84a174a3da2fb9e |
| institution | OA Journals |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-e6841d4a93ca4b6bb84a174a3da2fb9e2025-08-20T02:34:39ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12615Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in JapanNatsuki Miyake0Satoko Osuka1Isao Ohsawa2Takashi Tonoike3Tomoko Uno4Kazuo Tsuzuki5Bayasula6Reina Sonehara7Ayako Muraoka8Tomoko Nakamura9Maki Goto10Akira Iwase11Hiroaki Kajiyama12Department of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanHealth Service Center Aichi Gakuin University Nisshin JapanHealth Service Center Aichi Gakuin University Nisshin JapanHealth Service Center Aichi Gakuin University Nisshin JapanSchool of Human Care Studies Nagoya University of Arts and Sciences Nisshin JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanDepartment of Obstetrics and Gynecology Okazaki City Hospital Okazaki JapanDepartment of Obstetrics and Gynecology Gunma University Graduate School of Medicine Maebashi JapanDepartment of Obstetrics and Gynecology Nagoya University Graduate School of Medicine Nagoya JapanAbstract Purpose Polycystic ovary syndrome (PCOS) significantly affects women. This study investigated the association between serum anti‐Müllerian hormone (AMH) levels and menstrual cycle disorders, and AMH for PCOS in a general cohort of young Japanese women. Methods We measured serum AMH levels in 528 healthy female students at two universities in Japan between 2014 and 2020. We investigated the association between serum AMH levels and hormone levels, menstrual cycle, and body mass index. Results The mean (±standard deviation) AMH level was 4.78 ± 2.88 ng/mL. Correlations were observed between serum AMH and luteinizing hormone (LH) or LH/follicle‐stimulating hormone (FSH) levels in women with irregular menstruation (LH: r = 0.542, p < 0.001; LH/FSH: r = 0.584, p < 0.001). The optimal serum AMH cutoff value that predicted LH ≥7.1 IU/L and LH/FSH ≥1.21 (PCOS diagnostic criteria revised by Japan Society of Obstetrics and Gynecology) in women with menstrual irregularities was 5.30 ng/mL (area under the curve: 0.815, sensitivity: 84.2%, specificity: 70.3%). Conclusions Serum AMH can be measured during annual health checkups and may be a useful biomarker for early and arcuate diagnosis and intervention in women with PCOS.https://doi.org/10.1002/rmb2.12615anti‐Müllerian hormonemenstrual irregularitypolycystic ovary syndromepreconception carepuberty |
| spellingShingle | Natsuki Miyake Satoko Osuka Isao Ohsawa Takashi Tonoike Tomoko Uno Kazuo Tsuzuki Bayasula Reina Sonehara Ayako Muraoka Tomoko Nakamura Maki Goto Akira Iwase Hiroaki Kajiyama Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan Reproductive Medicine and Biology anti‐Müllerian hormone menstrual irregularity polycystic ovary syndrome preconception care puberty |
| title | Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan |
| title_full | Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan |
| title_fullStr | Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan |
| title_full_unstemmed | Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan |
| title_short | Association between anti‐Müllerian hormone levels and polycystic ovary syndrome in a general cohort of young women in Japan |
| title_sort | association between anti mullerian hormone levels and polycystic ovary syndrome in a general cohort of young women in japan |
| topic | anti‐Müllerian hormone menstrual irregularity polycystic ovary syndrome preconception care puberty |
| url | https://doi.org/10.1002/rmb2.12615 |
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