Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus)
Neuroendocrine tumors of the nasal cavity are rare in both animals and humans. This report describes the macroscopic, histopathological and immunohistochemical characteristics of a neuroendocrine tumor in a three-year-old female roe deer (Capreolus capreolus) that was shot due to a facial deformity...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1535432/full |
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| author | Gorazd Vengušt Diana Žele Vengušt Carlo Cantile Mitja Gombač Kristina Tekavec Tanja Švara |
| author_facet | Gorazd Vengušt Diana Žele Vengušt Carlo Cantile Mitja Gombač Kristina Tekavec Tanja Švara |
| author_sort | Gorazd Vengušt |
| collection | DOAJ |
| description | Neuroendocrine tumors of the nasal cavity are rare in both animals and humans. This report describes the macroscopic, histopathological and immunohistochemical characteristics of a neuroendocrine tumor in a three-year-old female roe deer (Capreolus capreolus) that was shot due to a facial deformity caused by an oval, firm, exophytic lesion effacing the left frontal and parietal regions. Longitudinal sectioning of the skull revealed a nasal cavity tumor that had invaded the cribriform plate, the rostral bones of the skull, the rostral aspect of the cranial cavity and the frontal sinuses and extended through the lacrimal, sphenoid and zygomatic bones into the subcutaneous tissue. Histopathologically, the tumor consisted of neoplastic cells forming sheets, nests, trabecular and cribriform structures separated by a delicate fibrovascular stroma. Mitoses were rare. Based on the histopathological and immunohistochemical findings, a neuroendocrine carcinoma was diagnosed. Based on thorough database searches, this is the first known case of a nasal neuroendocrine carcinoma in a roe deer. |
| format | Article |
| id | doaj-art-e67f3ba3cb52419d9f5465e3124014b6 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-e67f3ba3cb52419d9f5465e3124014b62025-02-05T07:32:47ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011210.3389/fvets.2025.15354321535432Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus)Gorazd Vengušt0Diana Žele Vengušt1Carlo Cantile2Mitja Gombač3Kristina Tekavec4Tanja Švara5Institute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaDepartment of Veterinary Sciences, University of Pisa, Pisa, ItalyInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaInstitute of Pathology, Wild Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana, Ljubljana, SloveniaNeuroendocrine tumors of the nasal cavity are rare in both animals and humans. This report describes the macroscopic, histopathological and immunohistochemical characteristics of a neuroendocrine tumor in a three-year-old female roe deer (Capreolus capreolus) that was shot due to a facial deformity caused by an oval, firm, exophytic lesion effacing the left frontal and parietal regions. Longitudinal sectioning of the skull revealed a nasal cavity tumor that had invaded the cribriform plate, the rostral bones of the skull, the rostral aspect of the cranial cavity and the frontal sinuses and extended through the lacrimal, sphenoid and zygomatic bones into the subcutaneous tissue. Histopathologically, the tumor consisted of neoplastic cells forming sheets, nests, trabecular and cribriform structures separated by a delicate fibrovascular stroma. Mitoses were rare. Based on the histopathological and immunohistochemical findings, a neuroendocrine carcinoma was diagnosed. Based on thorough database searches, this is the first known case of a nasal neuroendocrine carcinoma in a roe deer.https://www.frontiersin.org/articles/10.3389/fvets.2025.1535432/fullroe deernasal cavityneuroendocrine carcinomatumorimmunohistochemistry |
| spellingShingle | Gorazd Vengušt Diana Žele Vengušt Carlo Cantile Mitja Gombač Kristina Tekavec Tanja Švara Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) Frontiers in Veterinary Science roe deer nasal cavity neuroendocrine carcinoma tumor immunohistochemistry |
| title | Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) |
| title_full | Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) |
| title_fullStr | Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) |
| title_full_unstemmed | Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) |
| title_short | Case report: Neuroendocrine carcinoma of the nasal cavity in a roe deer (Capreolus capreolus) |
| title_sort | case report neuroendocrine carcinoma of the nasal cavity in a roe deer capreolus capreolus |
| topic | roe deer nasal cavity neuroendocrine carcinoma tumor immunohistochemistry |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1535432/full |
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