Development of Cardiovascular Disease Therapeutics Using Space Environment: Opportunities and Challenges
As research on the unique effects of space environment, especially microgravity and cosmic radiation, on the cardiovascular system is being conducted, research on the development of cardiovascular therapeutics using the space environment is attracting attention. This review comprehensively analyz...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Aerospace Medical Association of Korea
2025-03-01
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| Series: | Hanggong uju uihakoeji |
| Subjects: | |
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| Summary: | As research on the unique effects of space environment, especially microgravity and
cosmic radiation, on the cardiovascular system is being conducted, research on the
development of cardiovascular therapeutics using the space environment is attracting
attention. This review comprehensively analyzes the current status and prospects
of cardiovascular therapeutics development research utilizing space environment.
Microgravity environment has been shown to have a positive effect on the proliferation
and differentiation of cardiac progenitor cells and induced pluripotent stem cell-derived
cardio myocytes. Cardiac tissue culture and organoid technology have enabled more
effective drug screening and disease modeling than on the ground, and changes in gene
expression such as Aquaporin-4 have been found to play an important role in cardiac
function. Cosmic radiation can cause myocardial remodeling, fibrosis, and vascular
endothelial dysfunction, and the underlying mechanisms of these effects include
increased oxidative stress, promotion of inflammatory responses, deoxyribo nucleic acid
damage, and cell death. Currently, the development of drugs that can prevent or treat
cardiovascular damage caused by the space environment is in the early stages, and
future research is expected to focus on developing personalized treatments and exploring
the potential applications of space medicine research results to terrestrial medicine. |
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| ISSN: | 1738-2548 2713-9972 |