Discovery of <i>N</i>-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography

Discovery of <i>N</i>-(6-Methoxypyridin-3-yl)quinoline-2-amine Derivatives for Imaging Aggregated α-Synuclein in Parkinson’s Disease with Positron Emission Tomography

The fibrillary aggregation of α-synuclein is a hallmark of Parkinson’s disease (PD) and a potential target for diagnostics and therapeutics. Although substantial effort has been devoted to the development of positron emission tomography (PET) probes for detecting α-synuclein aggregates, no clinicall...

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Main Authors: Haiyang Zhao, Tianyu Huang, Dhruva D. Dhavale, Jennifer Y. O’Shea, Zsofia Lengyel-Zhand, Dinahlee Saturnino Guarino, Jiwei Gu, Xuyi Yue, Ying-Hwey Nai, Hao Jiang, Marshall G. Lougee, Vinayak V. Pagar, Hee Jong Kim, Benjamin A. Garcia, E. James Petersson, Chester A. Mathis, Paul T. Kotzbauer, Joel S. Perlmutter, Robert H. Mach, Zhude Tu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
α-synuclein aggregates
Parkinson’s disease
radiolabeling
PET imaging
tracer development
Online Access:https://www.mdpi.com/2073-4409/14/14/1108
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