Role of Neutrophil Apoptosis in the Resolution of Inflammation
Neutrophil granulocytes play a central role in host defense to infection and tissue injury. Their timely removal is essential for resolution of inflammation. Increasing evidence identified neutrophil apoptosis as an important control point in the development and resolution of inflammation. Delayed a...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.169 |
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| _version_ | 1832554260537016320 |
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| author | Driss El Kebir János G. Filep |
| author_facet | Driss El Kebir János G. Filep |
| author_sort | Driss El Kebir |
| collection | DOAJ |
| description | Neutrophil granulocytes play a central role in host defense to infection and tissue injury. Their timely removal is essential for resolution of inflammation. Increasing evidence identified neutrophil apoptosis as an important control point in the development and resolution of inflammation. Delayed apoptosis and/or impaired clearance of neutrophils aggravate and prolong tissue injury. This review will focus on outside-in signals that provide survival cues for neutrophils, the hierarchy of pro- and antiapoptotic signals, and molecular targets in the antiapoptotic signaling network that can be exploited by endogenously produced bioactive lipids, such as lipoxins or pharmacological inhibitors, including cyclin-dependent kinase inhibitors, to redirect neutrophils to apoptosis in vivo, thus promoting resolution of inflammation. |
| format | Article |
| id | doaj-art-e66221897d724df28a292dfd106db158 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e66221897d724df28a292dfd106db1582025-02-03T05:52:04ZengWileyThe Scientific World Journal1537-744X2010-01-01101731174810.1100/tsw.2010.169Role of Neutrophil Apoptosis in the Resolution of InflammationDriss El Kebir0János G. Filep1Research Center Maisonneuve-Rosemont Hospital, Department of Pathology and Cell Biology, University of Montreal, QC, CanadaResearch Center Maisonneuve-Rosemont Hospital, Department of Pathology and Cell Biology, University of Montreal, QC, CanadaNeutrophil granulocytes play a central role in host defense to infection and tissue injury. Their timely removal is essential for resolution of inflammation. Increasing evidence identified neutrophil apoptosis as an important control point in the development and resolution of inflammation. Delayed apoptosis and/or impaired clearance of neutrophils aggravate and prolong tissue injury. This review will focus on outside-in signals that provide survival cues for neutrophils, the hierarchy of pro- and antiapoptotic signals, and molecular targets in the antiapoptotic signaling network that can be exploited by endogenously produced bioactive lipids, such as lipoxins or pharmacological inhibitors, including cyclin-dependent kinase inhibitors, to redirect neutrophils to apoptosis in vivo, thus promoting resolution of inflammation.http://dx.doi.org/10.1100/tsw.2010.169 |
| spellingShingle | Driss El Kebir János G. Filep Role of Neutrophil Apoptosis in the Resolution of Inflammation The Scientific World Journal |
| title | Role of Neutrophil Apoptosis in the Resolution of Inflammation |
| title_full | Role of Neutrophil Apoptosis in the Resolution of Inflammation |
| title_fullStr | Role of Neutrophil Apoptosis in the Resolution of Inflammation |
| title_full_unstemmed | Role of Neutrophil Apoptosis in the Resolution of Inflammation |
| title_short | Role of Neutrophil Apoptosis in the Resolution of Inflammation |
| title_sort | role of neutrophil apoptosis in the resolution of inflammation |
| url | http://dx.doi.org/10.1100/tsw.2010.169 |
| work_keys_str_mv | AT drisselkebir roleofneutrophilapoptosisintheresolutionofinflammation AT janosgfilep roleofneutrophilapoptosisintheresolutionofinflammation |